目的:犬群病是一种皮肤病,是狗的主要全球健康问题。伊维菌素是治疗的首选药物,但它可能对携带多药耐药突变-1基因突变的狗造成毒性。因此,使用替代草药代替药物,如龙舌兰油(YN油),鼻草叶(WC),和藤黄果皮(MG)提取物。本研究旨在确定D.alatus油的功效,R.nasutusleaf,和G.mangostana果皮提取物对犬山药病的体内作用。
方法:检查了25只具有局部痴呆病的混种犬。狗通过深层皮肤刮擦被诊断为营养不良,并按照纳入标准进行筛查。每组五只狗在五个治疗组中进行治疗(伊维菌素,YN油,YN油+WC,YN油+MG,和YN油+WC+MG)1个月。对单个狗进行了临床评估,每天监测皮肤病变,持续60天。
结果:在用YN油+WC治疗的狗组中主要观察到皮肤损伤改善。这通过在治疗后第28天色素沉着过度和苔藓化消失以及在治疗后第56天脱发来证明。此外,治疗期间未观察到过敏或临床症状。
结论:YN油+WC是一种可用于治疗局部犬科病的替代草药。
OBJECTIVE: Canine demodicosis is a skin disease that is a major global health problem in dogs. Ivermectin is a drug of choice for treatment, but it may cause toxicity in dogs carrying multidrug resistance mutation-1 gene mutations. Hence, alternative herbal medicines are used instead of the drug, such as Dipterocarpus alatus oil (YN oil), Rhinacanthus nasutus leaf (WC), and Garcinia mangostana pericarps (MG) extracts. This study aimed to determine the efficacy of D. alatus oil, R. nasutus leaf, and G. mangostana pericarp extracts on canine demodicosis in vivo.
METHODS: Twenty-five mixed-breed dogs with localized demodicosis were examined. Dogs were diagnosed with demodicosis through deep skin scraping and screened with the inclusion criteria. Five dogs of each group were treated in five treatment groups (ivermectin, YN oil, YN oil+WC, YN oil+MG, and YN oil+WC+MG) for 1 month. The individual dogs were clinically evaluated, and the dermatological lesions were monitored daily for 60 days.
RESULTS: Dermatological lesion improvement was predominantly observed in the group of dogs treated with YN oil+WC. This was evidenced by the disappearance of the hyperpigmentation and lichenification on day 28 post-treatment and alopecia on day 56 post-treatment. Moreover, no allergic or clinical signs were observed during treatment.
CONCLUSIONS: YN oil+WC is an alternative herbal medicine that could be used for the treatment of localized canine demodicosis.