背景:我们对认知和大脑相互作用的理解仍然受到限制。虽然功能成像研究已经确定了认知大脑区域,认知功能的结构相关性仍未得到充分开发。像扩散磁共振成像(DMRI)这样的先进方法有助于探索大脑连通性和白质(WM)束微观结构。因此,我们对DMRI数据进行了连接测量法,揭示与认知相关的WM片段。
方法:纳入了来自美国国家心理健康研究所校内健康志愿者数据集的125名健康参与者。在WM区域内的DMRI衍生的定量各向异性(QA)值与Flanker抑制性控制和注意力测试(注意力)参与者的得分之间进行多元回归分析,尺寸变更卡片排序(执行功能),图像序列记忆测试(情节记忆),和列出排序工作记忆测试(工作记忆)任务从国家健康研究所工具箱。显著性水平设定为错误发现率(FDR)<0.05。
结果:我们确定了左小脑内WM束的QA与注意力的双侧穹窿之间的显着正相关,执行功能,和情景记忆(分别为FDR=0.018、0.0002和0.0002),双侧小脑内WM束的QA与注意力呈负相关(FDR=0.028)。工作记忆与左下纵肌和左下额枕骨束的QA呈正相关(FDR=0.0009),与右小脑道的QA呈负相关(FDR=0.0005)。
结论:我们的结果强调了认知表现与额叶WM完整性之间的复杂联系,temporal,和小脑区域,提供对认知障碍的早期发现和有针对性的干预措施的见解。
BACKGROUND: Our comprehension of the interplay of cognition and the brain remains constrained. While functional imaging studies have identified cognitive brain regions, structural correlates of cognitive functions remain underexplored. Advanced methods like Diffusion Magnetic Resonance Imaging (DMRI) facilitate the exploration of brain connectivity and White Matter (WM) tract microstructure. Therefore, we conducted connectometry method on DMRI data, to reveal WM tracts associated with cognition.
METHODS: 125 healthy participants from the National Institute of Mental Health Intramural Healthy Volunteer Dataset were recruited. Multiple regression analyses were conducted between DMRI-derived Quantitative Anisotropy (QA) values within WM tracts and scores of participants in Flanker Inhibitory Control and Attention Test (attention), Dimensional Change Card Sort (executive function), Picture Sequence Memory Test (episodic memory), and List Sorting Working Memory Test (working memory) tasks from National Institute of Health toolbox. The significance level was set at False Discovery Rate (FDR)<0.05.
RESULTS: We identified significant positive correlations between the QA of WM tracts within the left cerebellum and bilateral fornix with attention, executive functioning, and episodic memory (FDR=0.018, 0.0002, and 0.0002, respectively), and a negative correlation between QA of WM tracts within bilateral cerebellum with attention (FDR=0.028). Working memory demonstrated positive correlations with QA of left inferior longitudinal and left inferior fronto-occipital fasciculi (FDR=0.0009), while it showed a negative correlation with QA of right cerebellar tracts (FDR=0.0005).
CONCLUSIONS: Our results underscore the intricate link between cognitive performance and WM integrity in frontal, temporal, and cerebellar regions, offering insights into early detection and targeted interventions for cognitive disorders.