该方案公开了具有大环肽支架的单羧酸抑制剂的合成，以与GRB2SH2结构域结合并破坏GRB2和含磷酸酪氨酸的蛋白质之间的蛋白质-蛋白质相互作用（PPI）。
This protocol discloses the synthesis of monocarboxylic inhibitors with a macrocyclic peptide scaffold to bind with the GRB2 SH2 domain and disrupt the protein-protein interactions (PPIs) between GRB2 and phosphotyrosine-containing proteins.
