背景:舒芬太尼联合地佐辛或艾氯胺酮常用于术后镇痛。然而,缺乏疗效的临床证据。本研究比较了艾氯胺酮与地佐辛复合舒芬太尼对腹腔镜胆囊切除术(LC)后镇痛效果的影响。
方法:将58例患者随机分为艾氯胺酮组(ES组)和地佐辛组(DE组)。在ES组中,使用1.5mg/kg的艾氯胺酮。在DE组中,使用0.3mg/kg地佐辛。主要结果指标为4h时的视觉模拟量表(VAS)评分,8h,术后24h和48h。第二个结局指标为麻醉诱导前10分钟血清白细胞介素-6(IL-6)和C反应蛋白(CRP)水平,术后24h和48h。
结果:4小时的VAS分数,8h,术后24h和48hES组与DE组分别为2.70vs3.50(P=0.013),2.35vs3.15(P=0.004),1.69vs2.58(P=0.002),和1.50比2.26(P=0.002),分别。麻醉诱导前10分钟血清IL-6浓度,ES组和DE组术后24h和48h分别为34.39和34.12(P=0.901),112.33和129.60(P=0.014),89.69和108.46(P<0.001),分别。麻醉诱导前10分钟血清CRP水平,术后24h和48hES组和DE组分别为5.99和5.86(P=0.639),28.80和35.37(P<0.001),23.17和30.11(P<0.001),分别。
结论:对于LC术后疼痛,与0.3mg/kg地佐辛相比,1.5mg/kg的艾氯胺酮提供了更好的镇痛作用并降低了炎症水平。
背景:该试验于2023年5月31日在中国临床研究信息中心注册:https://www。chictr.org.cn/bin/home(注册号:ChiCTR2300072011)。
BACKGROUND: Sufentanil in combination with
dezocine or esketamine is often used for postoperative analgesia. However, there is a lack of clinical evidence of efficacy. This study compares the analgesic effects of esketamine and
dezocine combined with sufentanil for relieving pain after laparoscopic cholecystectomy(LC).
METHODS: A total of 58 patients were randomly assigned to the esketamine group (ES group) and
dezocine group (DE group). In the ES group, 1.5 mg/kg esketamine was used. In the DE group, 0.3 mg/kg
dezocine was used. Primary outcome measures were Visual Analog Scale (VAS) score at 4 h, 8 h, 24 h and 48 h after surgery. The second outcome measures were Interleukin-6 (IL-6) and C-reactive protein (CRP) levels in the serum 10 minutes before anesthesia induction, and at 24 h and 48 h after surgery.
RESULTS: The VAS scores at 4 h, 8 h, 24 h and 48 h after the surgery in the ES group vs DE group were 2.70 vs 3.50(P=0.013),2.35 vs 3.15(P=0.004),1.69 vs 2.58(P=0.002), and 1.50 vs 2.26(P=0.002), respectively. The serum IL-6 concentrations 10 minutes before anesthesia induction, and at 24 h and 48 h after surgery in the ES group and DE group were 34.39 and 34.12(P=0.901),112.33 and 129.60(P=0.014), and 89.69 and 108.46(P<0.001), respectively. The CRP levels in serum 10 minutes before anesthesia induction, and at 24 h and 48 h after the surgery in the ES group and DE group were 5.99 and 5.86(P=0.639), 28.80 and 35.37(P<0.001), and 23.17 and 30.11(P<0.001), respectively.
CONCLUSIONS: For postoperative pain after LC, 1.5mg/kg esketamine provided better analgesia and reduced inflammation levels than 0.3mg/kg
dezocine.
BACKGROUND: This trial was registered in the China Clinical Research Information Center in 31/05/2023 : https://www.chictr.org.cn/bin/home (Registration number: ChiCTR2300072011).