强迫症(OCS)在青春期很常见,但通常不符合强迫症的诊断阈值。然而,强迫症和阈值下OCS都与经历其他严重精神疾病的可能性增加有关。包括抑郁和自杀意念.不幸的是,关于OCS神经生物学的信息有限。
这里,我们对来自费城神经发育队列的大量青少年样本(分析n=832)进行了首次OCS脑成像研究。我们使用专注于不同神经解剖学尺度的互补分析方法研究了静息态功能磁共振成像的功能连通性。从已知的功能系统到全连接体测试。
我们发现了一个强大的全连接体模式,OCS相关差异,以及涉及已知功能系统的特定异常的证据,包括背侧和腹侧注意力,额顶叶,和默认模式系统。脑灌注成像和高分辨率结构成像分析未显示OCS相关差异,与功能连接的域特异性一致。
这里报道的大脑连接体与OCS的关联,连同其临床相关性的早期研究,支持OCS作为精神病风险的早期标志物的潜力,这可能会增强我们对青少年精神病理学发病机制的理解。
Obsessive-compulsive symptomatology (OCS) is common in adolescence but usually does not meet the diagnostic threshold for obsessive-compulsive disorder. Nevertheless, both obsessive-compulsive disorder and subthreshold OCS are associated with increased likelihood of experiencing other serious psychiatric conditions, including depression and suicidal ideation. Unfortunately, there is limited information on the neurobiology of OCS.
Here, we undertook one of the first brain imaging studies of OCS in a large adolescent sample (analyzed n = 832) from the Philadelphia Neurodevelopmental Cohort. We investigated resting-state functional magnetic resonance imaging functional connectivity using complementary analytic approaches that focus on different neuroanatomical scales, from known functional systems to connectome-wide tests.
We found a robust pattern of connectome-wide, OCS-related differences, as well as evidence of specific abnormalities involving known functional systems, including dorsal and ventral attention, frontoparietal, and default mode systems. Analysis of cerebral perfusion imaging and high-resolution structural imaging did not show OCS-related differences, consistent with domain specificity to functional connectivity.
The brain connectomic associations with OCS reported here, together with early studies of its clinical relevance, support the potential for OCS as an early marker of psychiatric risk that may enhance our understanding of mechanisms underlying the onset of adolescent psychopathology.