胰腺癌由于其攻击行为在肿瘤学领域提出了重大挑战。有限的治疗选择,和不利的前景。5年生存率只有10%,寻找有效的干预措施变得更加紧迫。组织增生与肿瘤微环境中的缺氧之间的复杂关系通过促进对化学疗法的抗性和阻碍治疗功效而进一步复杂化。致密的细胞外基质和与增生相关的癌症相关的成纤维细胞形成物理和生化屏障,阻碍药物渗透并促进免疫抑制环境。同时,低氧培养侵袭性肿瘤行为和对常规疗法的抵抗。对新兴药物和创新药物输送方法的全面探索。值得注意的是,基于纳米颗粒的递送系统的进步,局部药物输送植入物,并强调了携带氧气的策略在提高药物可及性和治疗效果方面的潜力.这些策略与传统化学疗法和靶向药物的整合揭示了增强治疗反应的协同作用的潜力。这些新兴的干预措施可以减轻血管增生和缺氧诱导的屏障,导致改善药物输送,治疗功效,和胰腺癌患者的预后。这篇综述文章探讨了新兴的抗癌药物和创新的药物输送策略的动态前景,这些策略有望克服胰腺癌治疗中血管增生和缺氧带来的挑战。
Pancreatic cancer poses a significant challenge within the field of oncology due to its aggressive behaviour, limited treatment choices, and unfavourable outlook. With a mere 10% survival rate at the 5-year mark, finding effective interventions becomes even more pressing. The intricate relationship between
desmoplasia and hypoxia in the tumor microenvironment further complicates matters by promoting resistance to chemotherapy and impeding treatment efficacy. The dense extracellular matrix and cancer-associated fibroblasts characteristic of
desmoplasia create a physical and biochemical barrier that impedes drug penetration and fosters an immunosuppressive milieu. Concurrently, hypoxia nurtures aggressive tumor behaviour and resistance to conventional therapies. a comprehensive exploration of emerging medications and innovative drug delivery approaches. Notably, advancements in nanoparticle-based delivery systems, local drug delivery implants, and oxygen-carrying strategies are highlighted for their potential to enhance drug accessibility and therapeutic outcomes. The integration of these strategies with traditional chemotherapies and targeted agents reveals the potential for synergistic effects that amplify treatment responses. These emerging interventions can mitigate
desmoplasia and hypoxia-induced barriers, leading to improved drug delivery, treatment efficacy, and patient outcomes in pancreatic cancer. This review article delves into the dynamic landscape of emerging anticancer medications and innovative drug delivery strategies poised to overcome the challenges imposed by
desmoplasia and hypoxia in the treatment of pancreatic cancer.