背景:来自各种来源的胶原肽在体外和临床试验中都显示出对健康和福祉的益处。然而,金枪鱼胶原蛋白肽对皮肤健康的研究很少。
目的:研究来自金枪鱼的胶原蛋白肽(Katsuwonuspelamis和Thunnusalbacares)对皮肤健康的影响,利用体外生物学研究和随机对照试验。
方法:在胶原和弹性蛋白合成和衰老细胞抑制方面评价了人真皮原代成纤维细胞的体外生物学研究。一个随机的,安慰剂对照,对72名妇女进行了双盲临床试验,这些妇女被随机分配接受金枪鱼胶原蛋白肽(n=36)或安慰剂(n=36)口服8周和2周后通过测量皮肤水合作用,经皮水分流失(TEWL),皮肤弹性,和皮肤密度。
结果:体外生物学效应表明,在增加胶原蛋白和弹性蛋白合成以及减少衰老细胞方面具有剂量依赖性的阳性结果。对胶原蛋白和衰老细胞的影响在高浓度时趋于稳定。一项临床试验表明,测试组皮肤水合作用显着增加,弹性,和密度,与基线相比,TEWL下降。除了面部的TEWL之外,测试组和安慰剂组在8周时显示出所有参数的统计学显著差异。即使在停药2周后,所有的积极作用也基本上得以保留。
结论:这些发现证明了金枪鱼胶原蛋白肽促进人类皮肤健康的巨大潜力,作为一种潜在的营养品,有必要进行进一步的调查。
BACKGROUND: Collagen peptides from various sources demonstrate benefits in health and well-being both in vitro and in clinical trials. However, there is a scarce study of collagen peptides from Tuna on skin health.
OBJECTIVE: To investigate the impact of collagen peptides derived from Tuna (Katsuwonus pelamis and Thunnus albacares) on skin health, utilizing in vitro biological studies and a randomized controlled trial.
METHODS: In vitro biological studies on human dermal primary fibroblasts were evaluated in terms of collagen and elastin synthesis and senescent cell inhibition. A randomized, placebo-controlled, double-blind clinical trial was conducted on 72 women who were randomly assigned to receive either tuna collagen peptides (n = 36) or a placebo (n = 36) orally for 8 weeks and 2 weeks post-ingestion by measuring skin hydration, transepidermal water loss (TEWL), skin elasticity, and skin
density.
RESULTS: In vitro biological effects demonstrated dose-dependent positive results in increasing collagen and elastin synthesis and reducing senescent cells. The effects on collagen and senescent cells plateaued at high concentrations. A clinical trial showed that the test group experienced a significant increase in skin hydration, elasticity, and
density, along with a decrease in TEWL compared to the baseline. The test and placebo groups showed statistically significant differences at 8 weeks for all parameters except for the TEWL at the face. All positive effects were substantially retained even after 2 weeks of discontinuation.
CONCLUSIONS: These findings demonstrate the significant potential of tuna collagen peptides to promote human skin health, warranting further investigation as a potential nutraceutical.