背景:尽管在区分阿尔茨海默病(AD)和额颞叶痴呆(bvFTD)的行为变异的诊断标准中考虑了记忆障碍的缺失,当前和越来越多的证据表明,相当比例的bvFTD病例存在情景记忆缺陷。为了比较AD和bvFTD患者的命名能力和情景记忆的表现,设计了本研究。
方法:对照组(32人)的横断面和分析研究。该研究包括42名可能患有AD的人和22名可能患有bvFTD的人,都超过60岁。使用西班牙语验证的统一数据集工具:多语言命名测试(MINT),Craft-21的历史和本森的复杂人物,在其他人中。
结果:AD患者的平均年龄更高。BvFTD患者的命名能力远低于AD患者,根据MINT和名词/动词命名系数测量。所有患有bvFTD的患者,73.81%的AD患者和只有31.25%的对照组未能识别Benson的复杂数字。所有差异均具有统计学意义(p<0.001)。
结果:这项研究证实了AD患者的健忘症特征,并揭示了bvFTD患者的命名能力下降,通常在执行功能早期受到影响的语言领域,根据最近的调查结果。
结论:AD患者在言语和视觉情景记忆任务中表现较差,而bvFTD患者在命名任务中表现较差。这些发现为探索前额叶参与情景记忆的机制提供了可能性,通常归因于海马体。
BACKGROUND: Although the absence of memory impairment was considered among the diagnostic criteria to differentiate Alzheimer\'s disease (AD) from Behavioural Variant of Frontotemporal Dementia (bvFTD), current and growing evidence indicates that a significant percentage of cases of bvFTD present with episodic memory deficits. In order to compare the performance profile of the naming capacity and episodic memory in patients with AD and bvFTD the present study was designed.
METHODS: Cross-sectional and analytical study with control group (32 people). The study included 42 people with probable AD and 22 with probable bvFTD, all over 60 years old. Uniform Data Set instruments validated in Spanish were used: Multilingual Naming Test (MINT), Craft-21 history and Benson\'s complex figure, among others.
RESULTS: A higher average age was observed among the patients with AD. The naming capacity was much lower in patients with bvFTD compared to patients with AD, measured according to the MINT and the nouns/verbs naming coefficient. All patients with bvFTD, 73.81% of those with AD and only 31.25% of the control group failed to recognise Benson\'s complex figure. All differences were statistically significant (p < 0.001).
RESULTS: This study confirms the amnesic profile of patients with AD and reveals the decrease in naming capacity in patients with bvFTD, an area of language that is typically affected early on with executive functions, according to recent findings.
CONCLUSIONS: Patients with AD perform worse in verbal and visual episodic memory tasks, while patients with bvFTD perform worse in naming tasks. These findings open the possibility of exploring the mechanisms of prefrontal participation in episodic memory, typically attributed to the hippocampus.