背景:睡眠持续时间与各种健康状况有关,包括慢性肾病.然而,韩国人群睡眠持续时间与肾功能下降之间的关系尚不清楚.本研究旨在探讨成人高血压患者睡眠时间对肾功能下降的影响。
方法:本队列研究使用从韩国基因组和流行病学研究获得的数据进行;纳入2,837例最初肾功能正常的高血压患者。在基线和整个16年的随访中估计肾小球滤过率(GFR)。如果一个人的GFR<60mL/min/1.73m2,则认为其肾功能下降。睡眠持续时间数据是通过访谈者辅助问卷获得的。睡眠持续时间被归类为短(<6小时),正常(≥6小时但<9小时),长(≥9小时)。应用Cox比例风险模型,对协变量进行调整。
结果:调整协变量后,睡眠持续时间与肾功能下降无关.然而,在基线时高血压控制不佳的男性中,与正常睡眠时间的男性相比,睡眠时间<6小时的男性肾功能下降的风险显著较高(风险比,1.56;95%置信区间,1.02-2.36)。
结论:短睡眠时间似乎与肾功能下降的风险增加无关;然而,这可能是高血压控制不佳的男性肾功能下降的危险因素。
BACKGROUND: Sleep duration is associated with various health conditions, including chronic kidney disease. However, the association between sleep duration and decline in kidney function in the South Korean population remains unclear. We aimed to investigate the impact of sleep duration on kidney function decline in adult patients with hypertension.
METHODS: This cohort study was performed using data obtained from the Korean Genome and Epidemiology Study; 2,837 patients with hypertension who initially had normal kidney function were included. Glomerular filtration rates (GFRs) were estimated at baseline and throughout the 16 years of follow-up. A person was considered to have a decline in kidney function if they had a GFR <60 mL/min/1.73 m2. Sleep duration data were obtained through interviewer-assisted questionnaires. Sleep durations were classified as short (<6 hours), normal (≥6 hours but <9 hours), and long (≥9 hours). The Cox proportional hazards model was applied, with adjustments for covariates.
RESULTS: After adjusting for covariates, sleep duration was not associated with a decline in kidney function. However, among men with poorly controlled hypertension at baseline, compared to men with normal sleep durations, men with sleep durations <6 hours had a significantly higher risk of kidney function decline (hazard ratio, 1.56; 95% confidence interval, 1.02-2.36).
CONCLUSIONS: Short sleep duration did not seem to be associated with an increased risk of decline in kidney function; however, it may be a risk factor for the decline in kidney function in men with poorly controlled hypertension.