未经授权:宫内期后颅窝畸形(PFA)的诊断和妊娠结局仍存在争议。PFA通常被称为母胎医学专家。PFA诊断的主要目的是筛查其他伴随的异常,向家庭提供预后信息,并讨论终止选项。
UNASSIGNED:这项回顾性研究是在2013年1月至2020年9月期间在三级围诊所诊断为PFA的患者中进行的。所有患者均常规进行孕中期超声筛查,在疑似异常的情况下通过胎儿MRI做出明确诊断。
未经评估:在2013年至2020年之间,对胎儿异常进行了164次胎儿MRI检查,22例胎儿MRI诊断为PFA。考虑到这些病例的胎儿MRI指征,四名患者(18%)被诊断为MegaCisternaMagna(MSM),两名患者被诊断为菱形脑突触,13例患者被诊断为Vermian发育不全-Dandy-Walker变异。剩下的两个病人,那些有神经管缺陷和腰骶NTD的人仍然活着。然而,在另一名患者中检测到无脑,并在产后死亡。
UNASSIGNED:PFA异常的诊断是复杂的,这是一种无法清楚预测哪些患者预后良好哪些患者预后不良的情况。预后不受母体和胎儿因素的影响,并且可以识别其他伴随的异常。胎儿MRI是一种可以提供回顾性检查和研究的成像方法,尤其是在预后不良的怀孕中。
The diagnosis of posterior fossa abnormalities (PFA) in the intrauterine period and association with pregnancy outcomes are still controversial. PFA is generally referred to maternal-fetal medicine specialists. The primary purpose of PFA diagnosis is to screen for other accompanying abnormalities, provide prognostic information to families, and discuss the termination option.
This retrospective study was conducted in patients diagnosed with PFA between January 2013 and September 2020 in a tertiary perinatology clinic. All patients underwent routine second-trimester ultrasound screening and definitive diagnosis was made by fetal magnetic resonance imaging (MRI) in the presence of a suspected anomaly.
There were 164 fetal MRIs for fetal abnormalities during the study period and 22 (13.4%) were diagnosed with a PFA on fetal MRI. Indications for fetal MRI included four (18%) with Mega Cisterna Magna, two (9.1%) with rhomboencephalosynapsis, and thirteen (59.1%) with Vermian Hypoplasia-Dandy-Walker variant. Two patients, with neural tube defects and lumbosacral neural-tube defect are still alive. However, iniencephaly was detected in last patient who died in the postnatal period.
Diagnosis of PFA abnormalities is complex, and the prognosis in PFA is often unclear. The prognosis is not affected by maternal and fetal factors and allows the recognition of additional accompanying abnormalities. Fetal MRI is an imaging method that can provide retrospective examination and research, especially in pregnancies with poor prognoses.