背景:传统方法无法清楚地可视化食管癌(EC)的肿瘤轮廓和转移,限制了达芬奇机器人辅助手术的临床应用。
目的:探讨达芬奇机器人联合纳米碳淋巴结示踪剂在EC根治术中的应用效果。
方法:总共,纳入柳州市工人医院2020年1月至2023年6月收治的104例早期EC患者。将患者分为观察组(n=52),术中使用纳米碳示踪剂进行了达芬奇机器人辅助微创食管切除术(RAMIE),和对照组(n=52),接受传统手术治疗。操作时间,术中失血,术后引流管留置时间,住院,解剖的淋巴结数量,并发症的发生率,并对远期疗效进行对比分析。术后应激反应C反应蛋白(CRP),皮质醇,评估肾上腺素(E)和炎症反应白细胞介素(IL)-6,IL-8,IL-10和肿瘤坏死因子-α(TNF-α)。
结果:与对照组相比,观察组患者术后CRP水平明显降低,皮质醇,和E水平(P<0.05),炎症反应较轻,IL-6、IL-10和TNF-α水平较低(P<0.05)。与传统手术相比,接受RAMIE的患者术中失血少,手术时间和住院时间短。平均切除淋巴结数,淋巴结清扫时间,观察组平均最小淋巴结直径均显著低于对照组(P<0.05)。观察组术后并发症发生率为5.77%,显著低于对照组的15.38%。此外,淋巴结转移率,再手术率,观察组12个月和24个月累计死亡率为1.92%,0%,0%,0%,分别,均显著低于对照组(P<0.05)。
结论:使用达芬奇机器人联合纳米碳淋巴结示踪剂治疗EC可取得良好的手术效果,具有良好的临床应用前景。
BACKGROUND: Traditional methods cannot clearly visualize esophageal cancer (EC) tumor contours and metastases, which limits the clinical application of da Vinci robot-assisted surgery.
OBJECTIVE: To investigate the efficacy of the da Vinci robot in combination with nanocarbon lymph node tracers in radical surgery of EC.
METHODS: In total, 104 patients with early-stage EC who were admitted to Liuzhou worker\'s Hospital from January 2020 to June 2023 were enrolled. The patients were assigned to an observation group (n = 52), which underwent da Vinci robot-assisted minimally invasive esophagectomy (RAMIE) with the intraoperative use of nanocarbon tracers, and a control group (n = 52), which underwent traditional surgery treatment. The operation time, intraoperative blood loss, postoperative drainage tube indwelling time, hospital stay, number of lymph nodes dissected, incidence of complications, and long-term curative effects were comparatively analyzed. The postoperative stress response C-reactive protein (CRP), cortisol, epinephrine (E) and inflammatory response interleukin (IL)-6, IL-8, IL-10, and tumor necrosis factor-alpha (TNF-α) were evaluated.
RESULTS: Compared with the control group, the observation group had significantly lower postoperative CRP, cortisol, and E levels (P < 0.05) with a milder inflammatory response, as indicated by lower IL-6, IL-10, and TNF-α levels (P < 0.05). Patients who underwent RAMIE had less intraoperative blood loss and shorter operation times and hospital stays than those who underwent traditional surgery. The average number of dissected lymph nodes, time of lymph node dissection, and mean smallest lymph node diameter were all significantly lower in the observation group (P < 0.05). The rate of postoperative complications was 5.77% in the observation group, significantly lower than the 15.38% observed in the control group. Furthermore, the lymphatic metastasis rate, reoperation rate, and 12- and 24-month cumulative mortality in the observation group were 1.92%, 0%, 0%, and 0%, respectively, all of which were significantly lower than those in the control group (P < 0.05).
CONCLUSIONS: The treatment of EC using the da Vinci robot combined with nanocarbon lymph node tracers can achieve good surgical outcomes and demonstrates promising clinical applications.