■非酒精性脂肪性肝病(NAFLD)是广泛存在于人类中的慢性疾病,患病率为美国人口的30%。1,2本研究的目标是验证定量超声算法在评估疑似NAFLD患者的肝脂肪变性中的性能。
■这项前瞻性研究共招募了31名临床怀疑NAFLD的患者,通过定量超声和参考MRI测量(质子密度脂肪分数,PDFF)。分析了基于原始超声RF(射频)数据和肝脏2DB模式图像的以下超声(US)参数,随后与MRI-PDFF相关:肝肾指数,声衰减系数,Nakagami系数参数,剪切波粘度,剪切波色散和剪切波弹性。超声参数也与高血压和糖尿病的存在相关。
■患者的平均(±SD)年龄和体重指数分别为49.03(±12.49)和30.12(±6.15),分别。在上述超声参数中,肝肾指数和声学衰减系数与肝脏脂肪变性的MRI-PDFF推导有很强的相关性,r值分别为0.829和0.765。其余的US参数均未显示与PDFF的强相关性。在有和没有高血压的患者中,Nakagami参数和声学衰减系数存在显着差异。
■肝肾指数和声学衰减系数与MRI-PDFF衍生的肝性脂肪变性的测量结果密切相关。定量超声是诊断和评估NAFLD患者的有前途的工具。
UNASSIGNED: Non-alcoholic fatty liver disease (NAFLD) is widespread chronic disease of the live in humans with the prevalence of 30% of the United States population.1,2 The goal of the study is to validate the performance of quantitative ultrasound algorithms in the assessment of hepatic steatosis in patients with suspected NAFLD.
UNASSIGNED: This prospective study enrolled a total of 31 patients with clinical suspicion of NAFLD to receive liver fat measurements by quantitative ultrasound and reference MRI measurements (proton density fat-fraction, PDFF). The following ultrasound (US) parameters based on both raw ultrasound RF (Radio Frequency) data and 2D B-mode images of the liver were analyzed with subsequent correlation with MRI-PDFF: hepatorenal index, acoustic attenuation coefficient, Nakagami coefficient parameter, shear wave viscosity, shear wave dispersion and shear wave elasticity. Ultrasound parameters were also correlated with the presence of hypertension and diabetes.
UNASSIGNED: The mean (± SD) age and body mass index of the patients were 49.03 (± 12.49) and 30.12 (± 6.15), respectively. Of the aforementioned ultrasound parameters, the hepatorenal index and acoustic attenuation coefficient showed a strong correlation with MRI-PDFF derivations of hepatic steatosis, with r-values of 0.829 and 0.765, respectively. None of the remaining US parameters showed strong correlations with PDFF. Significant differences in Nakagami parameters and acoustic attenuation coefficients were found in those patients with and without hypertension.
UNASSIGNED: Hepatorenal index and acoustic attenuation coefficient correlate well with MRI-PDFF-derived measurements of hepatic steatosis. Quantitative ultrasound is a promising tool for the diagnosis and assessment of patients with NAFLD.