DIABETES MELLITUS/complications

糖尿病 / 并发症
  • 文章类型: Journal Article
    背景:糖尿病患者容易发生微血管和大血管并发症,预防需要患者的积极作用。所以,健康素养应该在糖尿病患者的健康中发挥重要作用,但这种联系尚未完全理解。本研究的目的是了解健康素养与2型糖尿病(DM2)人群并发症患病率之间的关系。
    方法:这是一项多中心横向观察探索性研究。用两种健康素养工具进行了一项调查,医学术语识别测试(METER)和最新生命体征(NVS),由在葡萄牙三个主要地区的初级保健中心接受咨询的DM2患者填写。结果:在该样本中(n=141),50.6%为男性,41到88岁,56%的人比最低工资高。使用METER工具,发现57.4%的糖尿病患者具有功能素养。使用NVS工具发现有24.1%的识字率。同样使用NVS工具,发现36.2%的样本受试者的识字能力有限的可能性很高。利用METER工具,在有糖尿病并发症的个体中观察到健康素养的统计学显著下降(p=0.001).糖尿病并发症的存在与当前血压值之间没有显着关系,低密度脂蛋白,和社会经济指数。
    结论:在这项研究中,我们发现较低的健康素养与诊断出的DM2并发症之间存在显著关系(p=0.001).
    BACKGROUND: A person with diabetes is subject to developing micro and macrovascular complications and prevention requires an active role from the person. So, health literacy should have a preponderant role in the health of people with diabetes but this link is yet not fully understood. The objective of this study is to understand the relationship between health literacy and the prevalence of complications in people with diabetes mellitus type 2 (DM2).
    METHODS: This is a multicentric transversal observational exploratory study. A survey was conducted with two health literacy instruments, the Medical Term Recognition Test (METER) and Newest Vital Sign (NVS), filled out by people with DM2 coming to consultation in primary health centers in three main regions of Portugal.  Results: In this sample (n=141), 50.6% were male, 41 to 88 years old, and 56% earned more than the minimum wage. Using the METER tool, it was found that 57.4% of the diabetic patients had functional literacy. Adequate literacy was found in 24.1% with the NVS tool. Also with the NVS tool it was found that 36.2% of the sample subjects had s high probability of limited literacy. Utilizing the METER tool, a statistically significant decrease in health literacy was observed in individuals with diabetic complications (p=0.001). There was no significant relation between the presence of diabetic complications and present blood pressure values, low-density lipoprotein, and socioeconomic index.
    CONCLUSIONS: In this study, we found a significant relation between lower health literacy and the presence of diagnosed DM2 complications (p=0.001).
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  • 文章类型: Journal Article
    Diabetics and smokers are two patient groups at high risk for periodontal disease who also exhibit impaired wound healing and, therefore, constitute two different groups in whom the relationship between host-parasite interaction, outcome of periodontal therapy, and systemic factors is best represented. The results of two independent clinical trials involving treatment of periodontal disease in diabetics and smokers are presented. A new treatment regimen-for the management of periodontal disease associated with diabetes mellitus is proposed. This treatment approach incorporates both antimicrobial agents and pharmacological modulation of the host response. Elimination of periodontal infection and reduction of periodontal inflammation in diabetic patients resulted in a significant short-term reduction in the concentration of glycosylated hemoglobin (HbA1c ). Control of chronic infections and modulation of the host response offer a new therapeutic approach in the management of patients with both diabetes and periodontal disease. The effect of smoking on periodontal healing is also discussed. The clinical and microbiological response of smokers to non-surgical periodontal therapy is compared to non-smokers. In addition, possible mechanisms whereby diabetes mellitus and cigarette smoking increase the severity of periodontal disease are discussed. J Periodontol 1996;67:1094-1102.
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  • 文章类型: Journal Article
    糖尿病与心血管疾病患者的不良结局有关,包括心力衰竭.左心室辅助装置(LVAD)越来越多地用作晚期心力衰竭的救命疗法。LVAD前糖尿病对LVAD植入后长期结局的影响尚不清楚。在这项研究中,我们回顾性评估了现有糖尿病对LVAD后结局的影响.回顾了2006年至2013年288名LVAD接受者的数据。根据糖尿病病史对患者进行分层。基线人口统计,实验室,血液动力学,检查LVAD放置前的超声心动图信息,以及LVAD后主要不良结局的发生率.进行Kaplan-Meier分析和Cox回归分析。我们的队列包括122名糖尿病患者和166名无糖尿病患者。糖尿病组的平均糖化血红蛋白A1c水平为7.4%±1.6%。基线时糖尿病患者的医疗状况比非糖尿病患者更为不利。除了糖尿病组溶血发生率较高以外,两组之间的主要结局没有差异:12(10%)对5(3%);P=0.02。两组之间的生存结果没有差异。在这项研究中,糖尿病患者没有比非糖尿病患者有更差的生存或更多的不良结局。也许是因为改善了糖尿病控制,用LVAD治疗使心输出量正常化后或生化紊乱得到改善。糖尿病的诊断是溶血的独立预测因子。需要进一步研究以评估溶血与糖尿病之间的联系。
    Diabetes mellitus is associated with adverse outcomes in patients with cardiovascular diseases, including heart failure. Left ventricular assist devices (LVADs) are increasingly used as life-saving therapy for advanced heart failure. The effects of pre-LVAD diabetes on long-term outcomes after LVAD implantation are not well understood. In this study, we retrospectively evaluated the effect of existing diabetes on post-LVAD outcomes. Data on 288 LVAD recipients from 2006 through 2013 were reviewed. Patients were stratified in accordance with their histories of diabetes. Baseline demographic, laboratory, hemodynamic, and echocardiographic information before LVAD placement were reviewed, together with the post-LVAD incidence of major adverse outcomes. Kaplan-Meier analysis and Cox regression analysis were performed. Our cohort comprised 122 patients with diabetes and 166 patients without. The mean glycosylated hemoglobin A1c level in the diabetes group was 7.4% ± 1.6%. Diabetic patients at baseline had a more adverse medical profile than did nondiabetic patients. There were no differences in major outcomes between the 2 groups other than a higher incidence of hemolysis in the diabetes group: 12 (10%) vs 5 (3%); P=0.02. There was no difference in survival outcomes between the groups. Diabetic patients did not have worse survival or more adverse outcomes than did nondiabetic patients in this study, perhaps because of improved diabetes control, or improvement in biochemical derangements after normalization of cardiac output with LVAD therapy. A diagnosis of diabetes was an independent predictor of hemolysis. Further studies to evaluate the link between hemolysis and diabetes are indicated.
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