未经证实:自从近一个世纪前的首次乳房透视以来,使用光的乳腺癌成像已被认为在不同的实现旨在提高诊断,尽量减少可用活检的数量,或监控治疗。然而,由于强烈的光子散射,传统的光学成像产生低分辨率的图像,具有挑战性的量化和解释。光声成像解决了散射限制,并产生了光学对比度的高分辨率可视化,为乳腺癌成像提供了巨大的潜在价值。然而,由于多种因素,实验系统的图像质量仍然有限,包括具有深度和部分视角的信号衰减以及运动效果,特别是在多波长测量。
UNASSIGNED:我们开发了数据分析方法,以提高手持式光声乳腺癌成像的准确性,与超声检查一起产生第二代光声成像性能。
UNASSIGNED:我们通过手持光声检查人类乳腺癌和乳腺癌,制作了迄今为止最先进的图像,在分辨率和对比度方面。利用这些进步,我们检查了恶性肿瘤的光声标记,包括脉管系统异常,缺氧,和炎症,从乳腺癌患者那里获得的图像。
UNASSIGNED:我们通过对人体乳房的手持式检查,实现了光声图像的新质量水平,与常规超声检查相比,提高了混合光声超声(OPUS)检查的诊断和治疗潜力。
UNASSIGNED: Since the initial breast transillumination almost a century ago, breast cancer imaging using light has been considered in different implementations aiming to improve diagnostics, minimize the number of available biopsies, or monitor treatment. However, due to strong photon scattering, conventional optical imaging yields low resolution images, challenging quantification and interpretation. Optoacoustic imaging addresses the scattering limitation and yields high-resolution visualization of optical contrast, offering great potential value for breast cancer imaging. Nevertheless, the image quality of experimental systems remains limited due to a number of factors, including signal attenuation with depth and partial view angle and motion effects, particularly in multi-wavelength measurements.
UNASSIGNED: We developed data analytics methods to improve the accuracy of handheld optoacoustic breast cancer imaging, yielding second-generation optoacoustic imaging performance operating in tandem with ultrasonography.
UNASSIGNED: We produced the most advanced images yet with handheld optoacoustic examinations of the human breast and breast cancer, in terms of resolution and contrast. Using these advances, we examined optoacoustic markers of malignancy, including vasculature abnormalities, hypoxia, and inflammation, on images obtained from breast cancer patients.
UNASSIGNED: We achieved a new level of quality for optoacoustic images from a handheld examination of the human breast, advancing the diagnostic and theranostic potential of the hybrid optoacoustic-ultrasound (OPUS) examination over routine ultrasonography.