■自2019年以来,没有研究更新非风湿性退行性二尖瓣疾病(DMVD)的流行病学变化,因此本研究利用了全球疾病研究的数据。受伤,和风险因素2019(GBD2019)评估1990-2019年期间204个国家和地区的DMVD负担,以及患病率的变化,发病率,死亡和残疾调整寿命年(DALYs)的变化。
■使用GBD2019的结果,分析发病率,患病率,死亡,和DALYs费率,以及他们的年龄标准化率(ASR)。根据人类发展指数(HDI),社会人口指数(SDI),年龄,和性爱。
■2019年,全球现有DMVD病例为242.9万例(95%不确定区间(UI)23.081-2541.9万例),106.4万(95%UI1010.1-112.22万)新病例和0.034万(95%UI0.028-0.043万)死亡,和883万(95%UI0.754-109.2万)残疾调整寿命年。发病率,患病率,死亡,DMVD的DALYs及其ASR在性别上表现出显著差异,年龄组,regions,和国家从1990年到2019年。预计到2030年,女性DMVD的发病率将为72万,每10万人的ASR为15.59,51万男性,ASR为每100,000人口11.75,总发病率为123万,ASR为每10万人14.03。
■DMVD仍然是一个不容忽视的重大公共卫生问题,尽管全球发病率的ASR呈下降趋势,患病率,1990年至2019年的死亡人数和DALY。然而,我们注意到社会人口指数低和社会严重老龄化的国家出现了不利的发展趋势,性别不平等尤为突出。这表明需要重新定位当前的预防和治疗策略,随着一些国家卫生管理部门根据当地卫生制定相应的战略,防止DMVD增加,教育,经济条件,性别差异,和年龄差异。
UNASSIGNED: No studies have updated the epidemiologic changes in non-rheumatic degenerative mitral valve disease (DMVD) since 2019, thus this study utilized data from the Global Study of Diseases, Injuries, and Risk Factors 2019 (GBD2019) to assess the burden of DMVD in 204 countries and territories over the period 1990-2019, as well as changes in the prevalence, incidence, deaths and changes in disability-adjusted life years (
DALYs).
UNASSIGNED: Using the results from the GBD2019, analyzing the incidence, prevalence, deaths, and
DALYs rates, as well as their age-standardized rates (ASR). Based on the human development index (HDI), the socio-demographic index (SDI), age, and sex.
UNASSIGNED: In 2019, there were 24.229 million (95% uncertainty interval (UI) 23.081-25.419 million) existing cases of DMVD worldwide, with 1.064 million (95% UI 1.010-1.122 million) new cases and 0.034 million (95% UI 0.028-0.043 million) deaths, and 0.883 million (95% UI 0.754-1.092 million) disability-adjusted life years. The incidence, prevalence, deaths, and
DALYs of DMVD and their ASR showed significant differences across sex, age groups, regions, and countries from 1990 to 2019. It is projected that by 2030, the incidence of DMVD in females will be 0.72 million with an ASR of 15.59 per 100,000 population, 0.51 million in males with an ASR of 11.75 per 100,000 population, and a total incidence of 1.23 million with an ASR of 14.03 per 100,000 population.
UNASSIGNED: DMVD remains a significant public health problem that cannot be ignored, despite a decreasing trend in the ASR of global incidence, prevalence, deaths and
DALYs from 1990 to 2019. However, we note an adverse development trend in countries with low socio-demographic indexes and seriously aging societies, and sex inequality is particularly prominent. This indicates the need to reposition current prevention and treatment strategies, with some national health administrations developing corresponding strategies for preventing an increase in DMVD based on local health, education, economic conditions, sex differences, and age differences.