cayetanensis(C.cayetanensis)是一种重要的病原体,可引起腹泻病,并在美国和加拿大引起大型食源性腹泻暴发。然而,目前缺乏已发表的关于cayetanensis在全球人群中感染率的荟萃分析。对疾病患病率的真正估计应始终基于为此目的而设计的研究。我们对各种数据库进行了全面搜索,以查找有关人类中C.cayetanensis感染患病率的文章,从这些数据库开始到2023年3月10日。利用随机效应模型,我们估计了人类中C.cayetanensis感染的患病率。我们的分析包括来自42个不同国家的150个数据集,最终被选择用于最终的定量评估。据估计,全球人类中cayetanensis感染的患病率为3.4%(5636/166,611)。值得注意的是,非洲的患病率最高,为5.9%(606/11,068)。进一步的亚组分析显示,居住在低收入国家的人类感染率明显更高(7.6%,83/921)与中低收入国家(4.8%,3280/48,852),中上收入国家(2.9%,2194/99,419),和高收入国家(0.4%,79/17,419)。结果表明,全球人类cayetanensis感染的患病率相对较低,尽管地理分布广泛,但与成年人相比,儿童更容易感染cayetanensis。敏感性分析显示,一项研究显着影响cayetanensis的患病率,通过排除本研究,将其调整为2.9%(4017/160,049;95%CI:2.7-3.1%)。研究结果突出表明,在低收入国家和腹泻人群中,cayetanensis感染的患病率相对较高。尤其是在非洲。因此,在这些地区,对肠道原生动物的常规监测至关重要。
Cyclospora cayetanensis (C. cayetanensis) is a significant pathogen that causes diarrheal illness and causes large foodborne diarrhea outbreaks in the USA and Canada. However, there is currently a lack of published meta-analysis on the prevalence of C. cayetanensis infection in the global population. A real estimation of a disease prevalence should always be done on the basis of studies designed for that purpose. We conducted a comprehensive search of various databases for articles pertaining to the prevalence of C. cayetanensis infection in humans, spanning from the inception of these databases to March 10, 2023. Utilizing a random effects model, we estimated the prevalence of C. cayetanensis infection in humans. Our analysis included a total of 150 datasets sourced from 42 different countries, which were ultimately selected for the final quantitative assessment. The prevalence of C. cayetanensis infection in humans worldwide was estimated to be 3.4 % (5636/166,611). Notably, Africa exhibited the highest prevalence rate at 5.9 % (606/11,068). Further subgroup analysis revealed a significantly higher infection rate in humans residing in low-income countries (7.6 %, 83/921) compared to those in lower-middle-income countries (4.8 %, 3280/48,852), upper-middle-income countries (2.9 %, 2194/99,419), and high-income countries (0.4 %, 79/17,419). The results indicate that the global prevalence of C. cayetanensis infection in humans is relatively low, despite its extensive geographical distribution and children were found to be more susceptible to C. cayetanensis infection compared to those adults. Sensitivity analysis revealed that one study significantly affects the prevalence of C. cayetanensis, which was adjusted to 2.9 % (4017/160,049; 95 % CI: 2.7-3.1 %) by excluding this study. The findings highlight the relatively high prevalence of C. cayetanensis infection in low-income countries and among humans with diarrhea, particularly in Africa. Consequently, routine surveillance for intestinal protozoa is crucial in these regions.