Critical analysis

  • 文章类型: Journal Article
    水凝胶是具有满足理想伤口敷料的各种要求的一组特性的聚合物材料。让他们有希望进行伤口护理。这些功能包括,其中,吸收和保留大量水的能力以及紧密模仿天然结构的能力,如细胞外基质,促进各种细胞过程,如增殖和分化。用于水凝胶制剂的聚合物表现出广泛的性质,使它们可以分为两大类:天然聚合物,如胶原蛋白和壳聚糖,和合成聚合物,如聚氨酯和聚乙二醇。这篇综述提供了可以构成水凝胶的关键聚合物的全面概述和批判性分析,从聚合物的简短上下文开始。它深入研究了它们的功能,origin,和化学结构,突出提取和获取的关键来源。此外,这篇综述包括这些聚合物的主要固有特性及其在伤口愈合过程中的作用,陪伴,只要有,通过解释潜在的作用机制。它还解决了局限性,并描述了一些关于分离的聚合物在促进皮肤再生和伤口愈合方面的有效性的研究。随后,我们简要讨论了水凝胶在促进伤口愈合过程中的内在潜力的一些应用策略。由于它们在刺激血管生成中的作用,可以实现这一点,例如,或通过掺入生长因子或药物等物质,如抗菌药物,赋予水凝胶新的性能。除了物质掺入,水凝胶的潜力也与它们作为细胞培养的三维基质的能力有关。无论是将细胞加载到水凝胶中还是将细胞募集到伤口部位,它们在支架上增殖形成新的组织。后一种策略的前提是将生物传感器结合到水凝胶中,以实时监测伤口状况。如温度和pH。然后最终解决未来的前景。据我们所知,该手稿代表了第一个综合方法,该方法汇集并批判性地分析了在皮肤伤口愈合背景下构成水凝胶的天然和合成聚合物的基本方面。它将作为未来研究的基点,旨在为开发有效且环保的伤口敷料做出贡献。
    Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements of an ideal wound dressing, making them promising for wound care. These features include, among others, the ability to absorb and retain large amounts of water and the capacity to closely mimic native structures, such as the extracellular matrix, facilitating various cellular processes like proliferation and differentiation. The polymers used in hydrogel formulations exhibit a broad spectrum of properties, allowing them to be classified into two main categories: natural polymers like collagen and chitosan, and synthetic polymers such as polyurethane and polyethylene glycol. This review offers a comprehensive overview and critical analysis of the key polymers that can constitute hydrogels, beginning with a brief contextualization of the polymers. It delves into their function, origin, and chemical structure, highlighting key sources of extraction and obtaining. Additionally, this review encompasses the main intrinsic properties of these polymers and their roles in the wound healing process, accompanied, whenever available, by explanations of the underlying mechanisms of action. It also addresses limitations and describes some studies on the effectiveness of isolated polymers in promoting skin regeneration and wound healing. Subsequently, we briefly discuss some application strategies of hydrogels derived from their intrinsic potential to promote the wound healing process. This can be achieved due to their role in the stimulation of angiogenesis, for example, or through the incorporation of substances like growth factors or drugs, such as antimicrobials, imparting new properties to the hydrogels. In addition to substance incorporation, the potential of hydrogels is also related to their ability to serve as a three-dimensional matrix for cell culture, whether it involves loading cells into the hydrogel or recruiting cells to the wound site, where they proliferate on the scaffold to form new tissue. The latter strategy presupposes the incorporation of biosensors into the hydrogel for real-time monitoring of wound conditions, such as temperature and pH. Future prospects are then ultimately addressed. As far as we are aware, this manuscript represents the first comprehensive approach that brings together and critically analyzes fundamental aspects of both natural and synthetic polymers constituting hydrogels in the context of cutaneous wound healing. It will serve as a foundational point for future studies, aiming to contribute to the development of an effective and environmentally friendly dressing for wounds.
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  • 文章类型: Journal Article
    如何引用这篇文章:RajbanshiLK,ArjyalB.作者回复。印度J暴击护理中心2024;28(1):90-91。
    How to cite this article: Rajbanshi LK, Arjyal B. Author Response. Indian J Crit Care Med 2024;28(1):90-91.
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  • 2016年全国心理健康调查(NMHS2016)是一项大型流行病学研究,其中一种,由美国国家精神卫生与神经科学研究所(NIMHANS)进行,班加罗尔克服了以往调查的缺点。该研究的详细报告分为两个部分-“精神卫生系统”和“患病率”,模式和结果。虽然做得很全面,有一些不可避免的局限性。私营部门,该国的大量医疗保健提供者未参与调查.虽然MINI版本6.0是一个标准和结构化的工具,它不包括许多常见的精神疾病,如躯体形式障碍。Further,调查的方法使得很难准确计算个体主要精神疾病的患病率。已使用流行研究的标准清单对该调查进行了评估。报告中没有分享详细的定性数据。尚未详细说明传统的土著医疗保健系统和农村地区服务的可及性。因此,需要一个全面和文化敏感的评估工具,私营部门的参与,并强调加强资金供应以改善基础设施,这是调查后续阶段的未来方向。
    The National Mental Health Survey 2016 (NMHS 2016) was a large epidemiological study, one of its kind, conducted by the National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru to overcome the shortcomings of the previous surveys. The detailed report of the study is available in two parts- \'mental health systems\' and \'prevalence, pattern and outcomes\'. Though done comprehensively, there are some inevitable limitations. The private sector, a substantial health care provider in the country was not a participant in the survey. Though MINI version 6.0 is a standard and structured instrument, it does not cover many commonly encountered mental illnesses like somatoform disorders. Further, the methodology of the survey makes it difficult for an accurate calculation of the prevalence of individual major psychiatric disorders. The survey has been appraised using a standard checklist for prevalence studies. The detailed qualitative data has not been shared in the report. The contribution of the traditional indigenous systems of healthcare and accessibility of services in rural areas have not been elaborated. Thus, the need for a comprehensive and culturally sensitive assessment tool, involvement of the private sector, and enhancing funding provision to improve the infrastructure are emphasized as future directions for the subsequent phases of the survey.
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  • 文章类型: Journal Article
    这项研究表明木芙蓉具有丰富的药理潜力,探索其生物活性成分及其对健康和保健的治疗意义。尽管有很好的见解,全面的批判性分析对于确保科学严谨至关重要。为了解决这个问题,这项研究确立了明确的目标和目标,旨在通过细致的评估来审查研究结果。总之,这项研究,在解决这些关键点时,渴望为科学研究做出强有力的贡献,通过推进对H.sabdariffa治疗属性的理解,并促进在科学研究中采用可持续的方法。
    This study signifies the rich pharmacological potential of Hibiscus sabdariffa, exploring its bioactive components and their therapeutic implications for health and wellness. Despite the promising insights, a comprehensive critical analysis is essential to ensure scientific rigour. To address this, the study establishes clear aims and objectives, aiming to scrutinise the study findings through a meticulous assessment. In conclusion, this study, upon addressing these key points, aspires to offer a robust contribution to scientific research, by advancing the understanding of H. sabdariffa\'s therapeutic attributes and promoting the adoption of sustainable methodologies in scientific research.
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  • 文章类型: Journal Article
    体育素养(PL)已经在全球范围内被接受和整合,包括为残疾人士提供服务的组织。尽管它吸收了,最近的研究表明,对PL的理解反映了那些没有残疾的人的规范标准,导致实践削弱他人的独特和具体能力,同时验证能力。虽然最近发生了一种向认识和评价与PL相关的异质性的转变,能力主义的叙述仍然存在。因此,PL的可操作性直接与其概念化相矛盾,营造一种身体活动氛围,继续使残疾人士边缘化。考虑到这一点,本文批判性地解开PL,挑战现有的能力主义叙事,并提出提高强调PL的包容性水平的建议。途径,体育活动专业人员有助于繁殖能力倾向,将讨论。
    Physical literacy (PL) has been readily accepted and integrated globally, including organizations affording services to individuals experiencing disability. Despite its uptake, recent research has illustrated that understandings of PL reflect the normative standards of those who do not experience disability, leading to practices that diminish the unique and embodied capability of others while simultaneously validating ableism. While a shift towards recognizing and valuing the heterogeneity associated with PL has recently occurred, the ableist narrative persists. As a result, the operationalization of PL directly contradicts its conceptualization, fostering a physical activity climate that continues to marginalize individuals experiencing disability. With this in mind, this paper critically unpacks PL, challenging the existing ableist narrative and offering suggestions to heighten the level of inclusivity that underscores PL. Pathways, where physical activity professionals contribute to reproducing ableism, will be discussed.
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  • 文章类型: Journal Article
    自古以来,人们已经认识到,社会的组织及其分配资源是健康的主要决定因素。然而,学术和实践文献中对健康的大多数定义将其重点限制在个体对健康和功能能力的体验上,忽视个人所处的社会结构和过程。我们借鉴了卫生文献的关键卫生传播和关键唯物主义政治经济学的发展,以提供卫生的定义,将注意力集中在经济和政治制度在公平或不公平地分配卫生所需资源方面所发挥的作用。由于这些分布与个人独特的生物和心理倾向和情况相互作用,以产生健康,重要的是要确定他们的来源和使他们的分配更加公平的方法。因为人类是通过交流来解释社会的,自己,和其他人,一个简明的健康定义,提请注意这些社会特征及其在日常基础上促进或威胁健康的作用是至关重要的。
    It has been recognized since antiquity that the organization of society and how it distributes resources are the primary determinants of health. Yet most definitions of health in the academic and practice literatures limit their focus to the individual\'s experience of health and functional abilities, neglecting the structures and processes of societies in which the individual is embedded. We draw upon developments in the critical health communication and critical materialist political economy of health literatures to provide a definition of health that directs attention to the role that economic and political systems play in either equitably or inequitably distributing the resources necessary for health. Since these distributions interact with the individual\'s unique biological and psychological dispositions and situations to produce health, it is important to identify their sources and means of making their distributions more equitable. Because it is through communication that humans interpret society, themselves, and others, a concise definition of health that draws attention to these societal features and their roles on a day-to-day basis in promoting or threatening health is essential.
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  • 文章类型: Journal Article
    Griffiths铁磁体的铁磁到顺磁相变的临界行为,使用修改的Arrott图研究了Ho2NiMnO6,Kouvel-Fischer,和临界等温线分析。这里,我们报告了二阶相变,并从估计的临界指数得出结论,它是不寻常的,不属于常规的普遍性类别。然而,他们服从缩放关系,这表明相变温度附近相互作用的重新归一化。系统中格里菲斯相的存在说明了观察到的异常关键指数。
    The critical behavior at the ferromagnetic to paramagnetic phase transition of a Griffiths ferromagnet, Ho2NiMnO6, is studied using modified Arrott plot, Kouvel-Fisher, and critical isotherm analysis. Here, we report a second-order phase transition and conclude from the estimated critical exponents that it is unusual and do not belong to conventional universality classes. However, they obey scaling relationships, which indicates the renormalization of interactions around the phase transition temperature. The presence of Griffiths phase in the system accounts for the unusual critical exponents observed.
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  • 文章类型: Journal Article
    元启发式领域在自然系统中寻找灵感的历史悠久,从进化策略开始,遗传算法,和20世纪下半叶的蚁群优化。在过去的几十年里,然而,该领域经历了以隐喻为中心的方法的爆炸式增长,这些方法声称受到越来越荒谬的自然(甚至超自然)现象的启发-几种不同类型的鸟类,哺乳动物,鱼类和无脊椎动物,足球和排球,轮回,僵尸,和神。虽然隐喻可以成为强大的灵感工具,在不同的标签和命名下出现了数百个几乎无法识别的算法变体,这对该领域的科学进步起到了反作用,因为它既不会提高我们理解和模拟生物系统的能力,也不会为全局优化方法提供可推广的知识或设计原则。在本文中,我们讨论了这种趋势的一些可能原因,它对该领域的负面影响,以及一些旨在使元启发式领域在灵感和科学稳健性之间取得更好的平衡的努力。
    The field of metaheuristics has a long history of finding inspiration in natural systems, starting from evolution strategies, genetic algorithms, and ant colony optimization in the second half of the 20th century. In the last decades, however, the field has experienced an explosion of metaphor-centered methods claiming to be inspired by increasingly absurd natural (and even supernatural) phenomena-several different types of birds, mammals, fish and invertebrates, soccer and volleyball, reincarnation, zombies, and gods. Although metaphors can be powerful inspiration tools, the emergence of hundreds of barely discernible algorithmic variants under different labels and nomenclatures has been counterproductive to the scientific progress of the field, as it neither improves our ability to understand and simulate biological systems nor contributes generalizable knowledge or design principles for global optimization approaches. In this article we discuss some of the possible causes of this trend, its negative consequences for the field, and some efforts aimed at moving the area of metaheuristics toward a better balance between inspiration and scientific soundness.
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  • 文章类型: Journal Article
    在新自由主义大学里,奖学金,教育,学生,学术人员,和实践服从于管理需要。大学教育工作者因殖民新自由主义的做法而被诋毁和流离失所,这些做法系统地使学术工作无效和不可见。本文通过批判性地分析新自由主义管理主义在高等教育中的腐蚀性和奥威尔式运作,提供了一个例子,方法是我自己在教学中申请“对领导力的认可”的经验。我使用叙事人种学方法来对当代大学背景下学术实践的消除产生新的见解,并产生反霸权话语来理解这些过程。继哈贝马斯之后,有人认为,如果没有彻底的改革,(教育)生活世界的道德和实质层面与系统(新自由主义管理)战略的脱钩将使高等教育处于瘫痪状态。该分析强调了迫切需要抵抗,并为学者们提供了一个关键框架,以识别和质疑在自己的经验和背景下发生的类似殖民过程。
    Within the neoliberal university, scholarship, education, students, academic staff, and practices are subordinated to managerial imperatives. University educators are denigrated and displaced by colonising neoliberal practices that systemically invalidate and invisibilise academic work. The present article provides an example of this by critically analysing the corrosive and Orwellian operations of neoliberal managerialism in higher education through the prism of my own experience of applying for \'recognition of leadership\' in relation to teaching. I use a narrative ethnographic approach to generate new insights into the obliteration of academic practice in contemporary university contexts and to produce a counter-hegemonic discourse for understanding these processes. Following Habermas inter alia, it is argued that without radical reform, the uncoupling of the ethical and substantive dimensions of the (educational) lifeworld from systemic (neoliberal managerial) strategising will leave higher education in a state of paralysis. The analysis highlights the urgent need for resistance and provides a critical framework for academics to recognise and contest similar colonising processes occurring in their own experiences and contexts.
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  • 文章类型: Journal Article
    背景:在信息时代,患者很容易被不准确的互联网内容误导,因此,在医疗问题上没有做出明智的决定。腺样体肥大,儿童和青少年慢性上呼吸道阻塞的最常见原因之一,可能会导致严重的并发症,包括睡眠呼吸暂停和颅面改变.没有关于腺样体肥大网站质量的关键研究,对于没有医学背景的用户来说,确定哪个网站提供更可靠的信息是一个挑战。此外,访问谷歌等互联网搜索工具的障碍,雅虎,和其他人为中国大陆庞大的用户群体创造了一个孤立的互联网环境。互联网立法的差异,商业环境,和文化也可能导致中国大陆内外的在线健康信息质量不同。迄今为止,没有研究比较大陆中英文网站的质量差异。
    目的:本研究的目的是(1)分析患者可访问的有关腺样体肥大的网站的质量,(2)调查中英文网站的质量差异,(3)确定哪种类型的网站(例如,政府赞助,医疗保健提供者)在医疗信息方面更可靠,(4)确定外国网站的阻塞是否阻碍了用户访问中国大陆质量更好的网站。
    方法:收集了全球和中国大陆三大搜索引擎中显示的前100个网站(不包括广告),以作为数据源。网站是根据可访问性进行评估的,问责制,交互性,结构,和内容质量(准确性,内容覆盖,和客观性)。计算了科恩κ,进行单因素方差分析和Kruskal-Wallis检验,比较各组和亚组的结果.
    结果:英文网站内容质量的平均得分明显高于中文网站(Google为6.16vs4.94,P=.03,宾,和雅虎;百度6.16vs4.16,P<.001,搜狗,和必中国)。不受互联网审查系统影响的中国用户更有可能获得更高质量的在线医疗信息(4.94vs4.16,P=.02)。在组内Student-Newman-Keulsqposthoc分析中,专业组织和政府赞助的网站的质量普遍优于其他中英文网站(P<0.05)。
    结论:一般来说,有关腺样体肥大的英文网站质量优于中文网站;因此,居住在中国大陆以外的中国用户受到不准确的在线医疗信息的影响较小。
    BACKGROUND: In the information era, patients can easily be misled by inaccurate internet content, thus making not well-informed decisions about medical issues. Adenoid hypertrophy, one of the most common causes of chronic upper airway obstruction in children and adolescents, may lead to serious complications, including sleep apnea and craniofacial change. There have been no critical studies about the quality of websites on adenoid hypertrophy, posing a challenge for users without a medical background to determine which website offers more reliable information. Moreover, the blockage of access to internet search tools such as Google, Yahoo, and others has created an isolated internet environment for the enormous user population in mainland China. Differences in internet legislation, the commercial environment, and culture are also likely to result in varied quality of online health information inside and outside mainland China. To date, no study has compared the quality difference between mainland Chinese and English websites.
    OBJECTIVE: The aims of this study were to (1) analyze the quality of websites about adenoid hypertrophy accessible by patients, (2) investigate the quality differences between Chinese and English websites, (3) determine which type of website (eg, government-sponsored, health care provider) is more reliable in terms of medical information, and (4) determine whether the blockage of foreign websites is hindering users\' accessibility to better-quality websites in mainland China.
    METHODS: The first 100 websites (excluding advertisements) displayed on the top three search engines worldwide and in mainland China for the key search term \"enlarged adenoids\" were collected as the data source. The websites were evaluated based on accessibility, accountability, interactivity, structure, and content quality (accuracy, content coverage, and objectivity). Cohen κ was calculated, and one-way ANOVA and the Kruskal-Wallis test were performed to compare the results between groups and subgroups.
    RESULTS: The mean score for the content quality of English websites was significantly higher than that of Chinese websites (6.16 vs 4.94, P=.03 for Google, Bing, and Yahoo; 6.16 vs 4.16, P<.001 for Baidu, Sougou, and Bing China). Chinese users who are not influenced by the Internet Censorship System are more likely to access higher-quality online medical information (4.94 vs 4.16, P=.02). In within-group Student-Newman-Keuls q posthoc analysis, professional organization and government-sponsored websites were generally of better quality than other websites for both Chinese and English websites (P<.05).
    CONCLUSIONS: Generally, the English websites on adenoid hypertrophy are of better quality than Chinese websites; thus, Chinese users residing outside of the Chinese mainland are less influenced by inaccurate online medical information.
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