未经评估:冠状动脉和肺部疾病的联合检测具有临床意义,因为风险因素是共同的。在这项研究中,我们评估了一种用于心肺一体化采集的新型ECG门控锡过滤超低剂量胸部CT方案(GCCT),以及基于人工智能(AI)的冠状动脉钙评分的适用性.
UNASSIGNED:在接受心肺CT检查的10481例患者的临床登记中,在双源CT上对44例患者应用GCCT。120kVp的冠状动脉钙扫描(CCS),100kVp,和锡过滤100kVp(Sn100)的对照,与年龄相匹配,性别,和身体质量指数,从注册表中检索到(ntotal=176,66.5(59.4-74.0)年,52名男子)。在所有扫描中使用自动管电流调制。在接受GCCT和Sn100CCS的20例患者中,Agatston分数由专家和人工智能半自动测量,分为6组(0、<10、<100、<400、<1000、≥1000)。
未经评估:有效剂量从120kVpCCS(0.50(0.41-0.61)mSv)到100kVpCCS(0.34(0.26-0.37)mSv)到Sn100CCS(0.14(0.11-0.17)mSv)显着降低。尽管扫描长度更长,但GCCT显示出比Sn100CCS更高的值(0.28(0.21-0.32)mSv),但低于120kVp和100kVpCCS(所有p<0.05)。在半自动和基于AI的测量中,Agatston得分在GCCT和Sn100CCS之间密切相关(均ρ=0.98,p<0.001),导致Agatston得分分类高度一致(κ=0.97,95%CI0.92-1.00;κ=0.89,95%CI0.79-0.99)。关于胸部发现,对28例患者建议采取进一步的诊断步骤.
UNASSIGNED:GCCT允许超低辐射照射下可靠的冠状动脉疾病和肺癌筛查。GCCT衍生的Agatston分数与标准CCS表现出极好的一致性,导致等值风险分层。
UNASSIGNED: The combined testing for coronary artery and pulmonary diseases is of clinical interest as risk factors are shared. In this study, a novel ECG-gated tin-filtered ultra-low dose chest CT protocol (GCCT) for integrated heart and lung acquisition and the applicability of artificial intelligence (AI)-based coronary artery calcium scoring were assessed.
UNASSIGNED: In a clinical registry of 10481 patients undergoing heart and lung CT, GCCT was applied in 44 patients on a dual-source CT. Coronary calcium scans (CCS) with 120 kVp, 100 kVp, and tin-filtered 100 kVp (Sn100) of controls, matched with regard to age, sex, and body-mass index, were retrieved from the registry (ntotal=176, 66.5 (59.4-74.0) years, 52 men). Automatic tube current modulation was used in all scans. In 20 patients undergoing GCCT and Sn100 CCS, Agatston scores were measured both semi-automatically by experts and by AI, and classified into six groups (0, <10, <100, <400, <1000, ≥1000).
UNASSIGNED: Effective dose decreased significantly from 120 kVp CCS (0.50 (0.41-0.61) mSv) to 100 kVp CCS (0.34 (0.26-0.37) mSv) to Sn100 CCS (0.14 (0.11-0.17) mSv). GCCT showed higher values (0.28 (0.21-0.32) mSv) than Sn100 CCS but lower than 120 kVp and 100 kVp CCS (all p < 0.05) despite greater scan length. Agatston scores correlated strongly between GCCT and Sn100 CCS in semi-automatic and AI-based measurements (both ρ = 0.98, p < 0.001) resulting in high agreement in Agatston score classification (κ = 0.97, 95% CI 0.92-1.00; κ = 0.89, 95% CI 0.79-0.99). Regarding chest findings, further diagnostic steps were recommended in 28 patients.
UNASSIGNED: GCCT allows for reliable coronary artery disease and lung cancer screening with ultra-low radiation exposure. GCCT-derived Agatston score shows excellent agreement with standard CCS, resulting in equivalent risk stratification.