目的:产妇吸入家用产品对胎儿健康的影响存在担忧。本研究旨在阐明母亲接触家用产品的影响,包括喷雾配方,关于1岁以下后代的泌尿系统异常。
方法:本研究包括来自日本环境与儿童研究的84237名儿童的数据,正在进行的全国队列研究。使用产妇自我报告问卷,有关使用有机溶剂的信息,防水喷雾剂,驱虫喷雾剂,杀虫剂喷雾剂,从植入到妊娠中期或中期的除草剂,以及分娩后1年收集泌尿系统异常的数据。
结果:799名婴儿发生泌尿系统异常。多因素logistic回归分析调整为产妇年龄,孕期体重指数,妊娠期糖尿病,预先存在的母亲肾脏疾病,早产表明,母体暴露于有机溶剂与后代泌尿系统异常的患病率之间没有关联。然而,我们观察到孕期使用防水喷雾剂与男孩泌尿系统异常(比值比[OR]:1.28,95%置信区间[CI]:1.03~1.59)以及孕期使用杀虫剂喷雾剂与女孩泌尿系统异常(OR:1.48,95%CI:0.98~2.22)之间存在显著关联.亚分析显示,怀孕期间使用防水喷雾剂与男孩膀胱输尿管反流之间存在显着关联(OR:2.14,95%CI:1.02-4.49),怀孕期间使用杀虫剂喷雾剂与女孩肾积水之间存在显着关联(OR:2.23,95%CI:1.11-4.47)。
结论:怀孕期间使用喷雾制剂可能会增加后代泌尿系统异常的风险。
Concerns exist regarding the effects of maternal inhalation of household products on fetal health. This study aimed to clarify the impact of maternal exposure to household products, including spray formulations, on urological anomalies in offspring up to the age of 1 year.
This study included data from 84 237 children from the Japan Environment and Children\'s Study, an ongoing nationwide cohort study. Using maternal self-report questionnaires, information on the use of organic solvents, waterproof sprays, insect-repellent sprays, insecticide sprays, and herbicides from implantation until the second or third trimester of pregnancy and data on urological anomalies were collected 1 year after delivery.
Urological anomalies occurred in 799 infants. Multivariate logistic regression analysis adjusted for maternal age, pregnancy body mass index, gestational diabetes, pre-existing maternal kidney disease, and preterm birth revealed no association between maternal exposure to organic solvents and the prevalence of offspring urological anomalies. Nevertheless, we observed significant associations between waterproof spray use during pregnancy and urological anomalies in boys (odds ratio [OR]: 1.28, 95% confidence interval [CI]: 1.03-1.59) and between the use of insecticide spray during pregnancy and urological anomalies in girls (OR: 1.48, 95% CI: 0.98-2.22). Sub-analysis revealed significant associations between waterproof spray use during pregnancy and vesicoureteral reflux in boys (OR: 2.14, 95% CI: 1.02-4.49) and between the use of insecticide spray during pregnancy and hydronephrosis in girls (OR: 2.23, 95% CI: 1.11-4.47).
Spray formulation use during pregnancy might increase the risk of urological anomalies in the offspring.