目的:评估法国大陆2014年至2019年先天性甲状腺功能减退症(CH)和获得性甲状腺功能减退症(AH)的发生率。
方法:使用法国国家健康数据系统(SystèmeNationaledesDonnéesdeSanté,SNDS)。使用线性回归模型研究了时间趋势。使用Moran的全局指数(I)和统计方法以及空间关联的局部指标研究了空间分布。
结果:女性永久性CH的发病率每年增加8.9%(2014年:每100,000个出生年36.9[31.1-43.7]与2019:每100,000出生年51[43.9-59.3],p<0.01)。2014年至2019年,两位女性的AH发病率均有所下降(2014年:每100,000人年535.7[533.2-538.2],而2019年:每100,000人年335.5[333.6-337.4],p<0.01)和男性(2014年:每100,000人年197.5[195.9-199]与2019年:每100,000人年141.7[140.4-142.9],p<0.01)。在Nord-Pas-De-Calais和Lorraine地区(CH和AH),甲状腺功能减退的发生率很高。
结论:女性永久性CH的发病率随着时间的推移而增加。AH发病率下降。似乎有必要调查发病率分布差异中的环境因素。
OBJECTIVE: To assess the incidence of congenital hypothyroidism (CH) and acquired hypothyroidism (AH) between 2014 and 2019 in continental France.
METHODS: New cases of CH and AH were identified using the French National Health Data System (Système Nationale des Données de Santé, SNDS). Temporal trends were studied using linear regression models. Spatial distributions were studied using Moran\'s global index (I) and the statistical method and local indicators of spatial association.
RESULTS: The incidence of permanent CH in females increased by 8.9% per year (2014: 36.9 [31.1-43.7] per 100,000 birth-years vs. 2019: 51 [43.9-59.3] per 100,000 birth-years, p < 0.01). The incidence of AH decreased between 2014 and 2019 for both females (2014: 535.7 [533.2-538.2] per 100,000 person-years vs 2019: 335.5 [333.6-337.4] per 100,000 person-years, p < 0.01) and males (2014: 197.5 [195.9-199] per 100,000 person-years vs 2019: 141.7 [140.4-142.9] per 100,000 person-years, p<0.01). The incidence of hypothyroidism was high in the Nord-Pas-De-Calais and Lorraine regions (CH and AH).
CONCLUSIONS: The incidence of permanent CH in females has increased over time. AH incidence decreased. It seems necessary to investigate environmental factors in the disparity of incidence distribution.