■多重用药的主要并发症,这被称为同时使用五种以上的药物,是潜在的不适当的药物(PIMs),药物-药物,和药物-疾病相互作用。它的目的是准备一个辅助工具,以减少并发症的多重用药和支持合理用药(RDU),通过评估患者的年龄,毒品,和慢性疾病在这项研究中。
■在本研究的第一阶段,作为方法论研究,根据当前和有效的6个老年患者PIM标准,使用包含430种最常用药物和老年病慢性病的相互作用信息的数据库生成了一种最新和全面的辅助工具作为参考方法,和药物说明书,相关文章,和指导方针。然后,设计和开发了一个人工智能(AI)支持的Web应用程序,以促进该工具的实际使用。之后,一项横断面观察性单中心研究的数据被用于通过Web应用程序检测PIM的速率和时间以及药物相互作用.拟议的Web应用程序可在https://fastrational.com/上公开获得。
■虽然建议工具的PIM覆盖率为75.3%,欧盟(7)-PIM的PIM覆盖率,美国-FORTA,停止时间,啤酒2019,STOPP,Web应用程序数据库中的Priscus标准分别从最高到最低(63.5%-19.5%)。拟议的工具包括所有PIM,药物-药物,和其他标准检测到的药物-疾病相互作用信息。全科医生平均在2278秒内检测到没有网络应用程序的患者的交互,虽然使用Web应用程序的时间平均减少到33.8秒,这种情况具有统计学意义。
■在文献和本研究中,仅PIM标准不足以纳入积极使用的药物,且显示异质性.此外,许多研究表明,药物监管在实践中的最大障碍是“时间限制”。“提出的综合辅助工具分析年龄,毒品,和专门针对患者的疾病比手动方法快60倍,它提供了对相关参考文献的快速访问,并最终为临床医生支持RDU,第一个也是唯一一个AI支持的Web应用程序。
UNASSIGNED: The main complications of polypharmacy, which is known as the simultaneous use of more than five drugs, are potentially inappropriate medicines(PIMs), drug-drug, and drug-disease interaction. It is aimed to prepare an auxiliary tool to reduce the complications of polypharmacy and to support rational drug use(RDU), by evaluating the patient with age, drugs, and chronic diseases in this study.
UNASSIGNED: In the first phase of this study, as methodological research, an up-to-date and comprehensive auxiliary tool as a reference method was generated with a database containing interaction information of 430 most commonly used drug agents and chronic diseases in geriatrics in the light of current and valid 6 PIM criteria for geriatric patients, and medication prospectuses, relevant current articles, and guidelines. Then, an artificial intelligence(AI) supported web application was designed and developed to facilitate the practical use of the tool. Afterward, the data of a cross-sectional observational single-center study were used for the rate and time of PIM and drug interaction detection with the web application. The proposed web application is publicly available at https://fastrational.com/.
UNASSIGNED: While the PIM coverage rate with the proposed tool was 75.3%, the PIM coverage rate of EU(7)-PIM, US-FORTA, TIME-to-STOPP, Beers 2019, STOPP, Priscus criteria in the web application database respectively(63.5%-19.5%) from the highest to the lowest. The proposed tool includes all PIMs, drug-drug, and drug-disease interaction information detected with other criteria. A general practitioner detects interactions for a patient without the web application in 2278 s on average, while the time with the web application is decreased to 33.8 s on average, and this situation is statistically significant.
UNASSIGNED: In the literature and this study, the PIM criteria alone are insufficient to include actively used medicines and it shows heterogeneity. In addition, many studies showed that the biggest obstacle to drug regulation in practice is \"time constraints.\" The proposed comprehensive auxiliary tool analyzes age, drugs, and diseases specifically for the patient 60 times faster than the manual method, and it provides quick access to the relevant references, and ultimately supports RDU for the clinician, with the first and only AI-supported web application.