随着提取和表征活性成分的技术的进步,从自然界衍生的天然物质的发展提出了重大挑战。Hispolon近年来受到了很多关注,归因于其广泛的生物活性。它是从几种蘑菇物种中提取的酚类分子,例如桑黄,Phellinuslinteus,金黄黄鱼,PhellinusMerrillii,和Hispidus.为了全面概述hispolon的药理活性,这篇评论强调了它的抗癌,抗炎,抗氧化剂,抗菌,和抗糖尿病活性。几个科学研究数据库,包括谷歌学者,WebofScience,PubMed,SciFinder,SpringerLink,科学直接,Scopus,and,WileyOnline一直用于收集有关hispolon的数据,直到2024年5月。体外和体内研究表明,hispolon通过修饰包括细胞凋亡在内的几个信号通路表现出显著的抗癌特性,周期逮捕,自噬,抑制血管生成和转移。Hispolon的抗菌活性被证明对许多细菌,真菌,和病毒病原体,强调其作为一种新型抗菌剂的潜在用途。此外,hispolon通过抑制关键炎症介质显示出有效的抗炎活性,如诱导型NO合酶(iNOS),肿瘤坏死因子-α(TNF-α),和环氧合酶-2(COX-2),以及丝裂原活化蛋白激酶(MAPK)和核因子κB(NF-κB)信号通路的调节。hispolon的抗氧化潜力归因于其中和活性氧(ROS)并增加抗氧化酶活性的能力,表明可能参与预防氧化应激相关疾病。Hispolon的抗糖尿病活性与醛糖还原酶和α-葡萄糖苷酶的抑制有关。关于hispolon的研究强调了它作为一种有前途的支架的潜在用途,用于开发针对各种疾病的新型治疗剂,包括癌症,传染病,炎症性疾病,和糖尿病。
The development of natural substances derived from nature poses a significant challenge as technologies for the extraction and characterization of active principles advance. Hispolon has received a lot of attention in recent years, ascribable to its wide range of biological activities. It is a phenolic molecule that was extracted from several mushroom species such as Phellinus igniarius, Phellinus linteus, Phellinus lonicerinus, Phellinus merrillii, and Inonotus hispidus. To provide a comprehensive overview of the pharmacological activities of hispolon, this review highlights its anticancer, anti-inflammatory, antioxidant, antibacterial, and anti-diabetic activities. Several scientific research databases, including Google Scholar, Web of Science, PubMed, SciFinder, SpringerLink, Science Direct, Scopus, and, Wiley Online were used to gather the data on hispolon until May 2024. The in vitro and in vivo studies have revealed that hispolon exhibited significant anticancer properties through modifying several signaling pathways including cell apoptosis, cycle arrest, autophagy, and inhibition of angiogenesis and metastasis. Hispolon\'s antimicrobial activity was proven against many bacterial, fungal, and viral pathogens, highlighting its potential use as a novel antimicrobial agent. Additionally, hispolon displayed potent anti-inflammatory activity through the suppression of key inflammatory mediators, such as inducible NO synthase (iNOS), tumor necrosis factor-α (TNF-α), and cyclooxygenases-2 (COX-2), and the modulation of mitogen-activated protein kinases (MAPK) and nuclear factor kappa B (NF-κB) signaling pathways. The antioxidant potential of hispolon was attributed to its capacity to neutralize reactive oxygen species (ROS) and to increase the activity of antioxidant enzymes, indicating a possible involvement in the prevention of oxidative stress-related illnesses. Hispolon\'s antidiabetic activity was associated with the inhibition of aldose reductase and α-glucosidase. Studies on hispolon emphasized its potential use as a promising scaffold for the development of novel therapeutic agents targeting various diseases, including cancer, infectious diseases, inflammatory disorders, and diabetes.