背景:炎性和非炎性痤疮病变在痤疮受试者中构成了重大的临床挑战。
目的:评估面部精华液和含有水杨酸和硫辛酸的面膜改善皮肤状况的有效性和安全性。
方法:这项随机对照试验包括患有粉刺的成年人,上海的炎症后红斑(PIE)和/或色素沉着过度(PIH),2021年7月中国。参与者被随机分配1:1接受研究血清+面罩或单独的血清8周。痤疮严重程度,粉刺,丘疹,脓疱,派,PIH,皮肤毛孔,肤色均匀度,皮脂分泌,皮肤水合作用,并在T0d评估经表皮失水,T1d,T7d,T14d,T28d,T56d
结果:83名参与者被纳入,包括血清+面罩和血清组的41和42,分别。痤疮严重程度,皮肤毛孔的密度,肤色均匀度,PIH集中在脸上,PIE集中在鼻子上,PIE和PIH的强度,闭合的粉刺在脸上,鼻子上的开放粉刺,皮脂分泌,治疗8周后,两组皮肤水化均较基线明显改善(均p<0.05)。添加掩模改善了闭合粉刺的数量(-6.56±0.39与-5.19±0.44,p=0.022)和痤疮严重程度(-0.39±0.08vs.-0.12±0.09,p=0.026)明显高于单独使用血清。两组均无不良反应报告。
结论:研究血清通过调节皮肤屏障功能和达到皮肤水合和皮脂分泌的平衡来改善皮肤状况,去除粉刺,改善PIE和PIH。面罩的添加在不损害安全性的情况下加速了效果。
BACKGROUND: Inflammatory and non-inflammatory acne lesions constitute a significant clinical challenge in acne subjects.
OBJECTIVE: To evaluate the efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid for improving skin conditions.
METHODS: This randomized controlled trial included adults with
comedones, post-inflammatory erythema (PIE) and/or hyperpigmentation (PIH) in Shanghai, China in July 2021. Participants were randomly assigned 1:1 to receive the study Serum + Mask or serum alone for 8 weeks. Acne severity,
comedones, papules, pustules, PIE, PIH, skin pores, skin tone evenness, sebum secretion, skin hydration, and trans-epidermal water loss were evaluated at T0d, T1d, T7d, T14d, T28d, and T56d.
RESULTS: Eighty-three participants were included, including 41 and 42 in the Serum + Mask and Serum groups, respectively. Acne severity, density of skin pores, skin tone evenness, PIH foci on face, PIE foci on nose, intensity of PIE and PIH, closed
comedones on face, open
comedones on nose, sebum secretion, and skin hydration were significantly improved from baseline after 8 weeks of treatment in both groups (all p < 0.05). Addition of the mask improved the number of closed
comedones (-6.56 ± 0.39 vs. -5.19 ± 0.44, p = 0.022) and acne severity (-0.39 ± 0.08 vs. -0.12 ± 0.09, p = 0.026) substantially more than using the serum alone. No adverse reaction was reported in either group.
CONCLUSIONS: The study serum improved skin conditions by regulating skin barrier function and achieving a balance of skin hydration and sebum secretion, removing comedones and improving PIE and PIH. Addition of the mask accelerated the effects without compromising safety.