背景:胶原瘤是由真皮胶原组成的罕见结缔组织错构瘤。感染人类免疫缺陷病毒(HIV)的患者可能会出现与HIV相关的脂肪营养不良或脂肪瘤。HIV和胶原瘤之间没有已知的关联。
方法:在这里,我们描述了一例接受ART治疗的HIV患者的孤立性胶原瘤。病变是7x4厘米的皮下结节,枕骨头皮上没有表皮变化。这个病灶被切除了,组织病理学显示厚而随机排列的胶原束,与胶原瘤一致.
结论:该病例代表一例HIV患者中出现的孤立的胶原瘤。尚不清楚HIV或ART是否促成了这种胶原瘤的发展。胶原瘤的治疗包括手术切除和病灶内皮质类固醇。除了脂肪瘤或脂肪营养不良,对于表现为孤立的大型皮下硬结结节的患者,在鉴别诊断中保持胶原瘤很重要。
BACKGROUND: Collagenomas are rare connective tissue hamartomas composed of dermal collagen. Patients infected with human immunodeficiency virus (HIV) can present with HIV-related lipodystrophy or lipomas. There are no known associations between HIV and collagenomas.
METHODS: Here we describe a case of an isolated
collagenoma in an HIV patient on ART. The lesion was a seven by four-centimeter subcutaneous nodule with no epidermal changes located on the occipital scalp. This lesion was excised, and histopathology showed thick and randomly arranged collagen bundles, consistent with a
collagenoma.
CONCLUSIONS: This case represents an isolated
collagenoma presenting in a patient with HIV. It is unclear whether HIV or ART contributed to the development of this
collagenoma. Treatment of collagenomas include surgical excision and intralesional corticosteroids. In addition to lipoma or lipodystrophy, it is important to keep
collagenoma in the differential diagnosis in a patient presenting with an isolated large indurated subcutaneous nodule.