■严重发热伴血小板减少综合征(SFTS)是一种由新型布尼亚病毒感染引起的新兴传染病,具有高致死率。目的探讨SFTS患者凝血指标的变化,旨在为早期诊断提供临床证据,治疗,和疾病分析。
■选择2020年4月1日至2022年5月21日在南京鼓楼医院就诊的SFTS患者40例,按病程分组,轻度和重度疾病,治愈和死亡,以50名健康体检者为对照,使用ROC曲线预测严重和死亡疾病的风险。
■健康者之间的比较轻度和重度组显示PT,INR,APTT,TT,D-D和vWF水平高于健康对照组,FII,FIX,FX,FXI,FXII,PC和PS水平低于健康对照组,差异有统计学意义(p<0.05)。比较不同疗程的SFTS患者的结果,Fib的结果,FV,FVII,FVIII,FIX,FX,FXI有统计学意义(p<0.05)。在幸存和死亡的病人中,PT,INR,死亡患者的DD和PS结果高于存活患者,和FVIII,FIX,FXI,FXII和PC低于存活患者。ROC曲线下面积显示D-D对严重疾病风险具有较高的预测能力(AUROC0.93,在1.50mg/L的临界值时的敏感性和特异性分别为90.0和86.5%,分别)和死亡发生的风险(AUROC0.84,在截止值为3.39mg/L时的敏感性和特异性分别为87.5%和80.0%,分别)。
■监测SFTS患者的凝血参数对于确定患者病情的严重程度和死亡具有重要意义,提供早期关注具有很大的临床价值,及时干预,最大限度地降低有严重疾病风险的患者的死亡率。
UNASSIGNED: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus infection with a high lethality rate. The purpose of this study was to investigate the changes in coagulation parameters in patients with SFTS, aiming to provide clinical evidence for early diagnosis, treatment, and disease analysis.
UNASSIGNED: A total of 40 patients with SFTS attended from April 1, 2020 to May 21, 2022 in Nanjing Drum Tower Hospital were selected and grouped according to the duration of the disease, mild and severe disease, cure and death, with 50 healthy physical examiners as controls, and the risk of severe and death disease was predicted using ROC curves.
UNASSIGNED: Comparison between the healthy, mild and severe groups revealed that PT, INR, APTT, TT, D-D and vWF levels were higher than those in the healthy control group, and FII, FIX, FX, FXI, FXII, PC and PS levels were lower than those in the healthy control group, the differences were statistically significant (p < 0.05). Comparing the results of SFTS patients with different course times, the results of Fib, FV, FVII, FVIII, FIX, FX, FXI were statistically significant (p < 0.05). Among the survived and deceased patients, the PT, INR, DD and PS results of the deceased patients were higher than those of the survived patients, and the FVIII, FIX, FXI, FXII and PC were lower than those of the survived patients. The area under the ROC curve showed that D-D had higher predictive ability for the risk of severe disease (AUROC 0.93, sensitivity and specificity at a Cut-off value of 1.50 mg/L were 90.0 and 86.5%, respectively) and the risk of death occurring (AUROC 0.84, sensitivity and specificity at a Cut-off value of 3.39 mg/L were 87.5 and 80.0%, respectively).
UNASSIGNED: The monitoring of the coagulation parameters in patients with SFTS is great significance for identifying the severity and death of the patient\'s condition, and it is of great clinical value to provide early attention, timely intervention and maximum reduction of the mortality rate for patients at risk of severe disease.