背景:由于粪肠球菌中抗生素耐药性的出现(E.粪肠),它表明是潜在的机会病原体,导致世界各地各种医疗保健相关和危及生命的疾病。
目的:本荟萃分析的目的是评估临床粪肠球菌分离株的加权合并耐药率,区域,抗菌药物敏感性试验(AST),和感染源。
方法:我们搜索了PubMed中的研究,Scopus,和WebofScience(2022年11月30日)。所有统计分析均使用统计软件包R进行。
结果:该分析涵盖了在28个国家进行的总共74项研究。根据元回归,氯霉素,磷霉素,亚胺培南,利奈唑胺,米诺环素,诺氟沙星,quinupristin-dalfopristin,四环素耐药率随时间增加。分析显示,氨苄西林的抗生素耐药率存在统计学上的显着差异,氯霉素,红霉素,庆大霉素,青霉素,利福平,替考拉宁,四环素,和万古霉素在不同的国家。
结论:全球,耐药粪肠球菌菌株的患病率随着时间的推移而增加。达托霉素和替加环素可以是治疗临床粪肠球菌感染的有效药物。考虑到欧洲和澳大利亚大陆抗生素耐药性的低患病率,建议利用他们的预防策略,以便在其他耐药率高的地方获得有效的结果。
BACKGROUND: Due to the increasing emergence of antibiotic resistance in Enterococcus faecalis (E. faecalis), it indicated as potentially opportunistic pathogen causing various healthcare-associated and life-threatening diseases around the world.
OBJECTIVE: The aim of this meta-analysis was to evaluate the weighted pooled resistance rates in clinical E. faecalis isolates based on over time, areas, antimicrobial susceptibility testing (AST), and infection source.
METHODS: We searched the studies in PubMed, Scopus, and Web of Science (November 30, 2022). All statistical analyses were carried out using the statistical package R.
RESULTS: The analysis encompassed a total of 74 studies conducted in 28 countries. According to the meta-regression, the chloramphenicol, fosfomycin, imipenem, linezolid, minocycline, norfloxacin, quinupristin-dalfopristin, and tetracycline resistance rate increased over time. Analysis revealed statistically significant differences in antibiotic resistance rates for ampicillin, chloramphenicol, erythromycin, gentamicin, penicillin, rifampicin, teicoplanin, tetracycline, and vancomycin across various countries.
CONCLUSIONS: Globally, the prevalence of drug resistant E. faecalis strains are on the increase over time. Daptomycin and tigecycline can be an effective agent for the treatment of clinical E. faecalis infections. Considering the low prevalence of antibiotic resistance in continents of Europe and Australia, it is suggested to take advantage of their preventive strategies in order to obtain efficient results in other places with high prevalence of resistance.