背景:约15%的妊娠以流产告终。由于大多数研究都集中在母亲因素上,关于父亲因素对成功怀孕机会的影响知之甚少。
目的:这项队列研究旨在评估生化妊娠的机会,临床妊娠,以及男性伴侣患有糖尿病(DM)的夫妇中的活产子女。
方法:我们进行了一项全国性的队列研究。包括2006年至2019年接受辅助生殖技术治疗的夫妇。暴露队列包括父系1型DM(T1DM)夫妇的胚胎移植,2型DM(T2DM),或混合型DM(TMDM)。未暴露的队列包括没有父系DM的夫妇的胚胎移植。
结果:共包括101,875个胚胎移植。其中,503名男性患有T1DM,225名男性患有T2DM,263名男性患有TMDM,和100,884没有DM。对于父系T1DM,实现生化妊娠的校正OR,临床妊娠,活产婴儿为0.97(95%CI0.77-1.23),1.08(95%CI0.65-1.79),和0.75(95%CI0.49-1.14),分别。对于父系T2DM,实现生化妊娠的校正OR,临床妊娠,活产婴儿为0.80(95%CI0.56;1.16),0.67(95%CI0.32-1.41),和1.03(95%CI0.48-2.20),分别。对于父亲的TMDM,实现生化妊娠的校正OR,临床妊娠和活产为0.95(95%CI0.67-1.33),1.31(95%CI0.56-2.92),和1.19(95%CI0.59-2.38),分别。
结论:父系DM与生化妊娠几率降低无统计学意义,临床妊娠,或活产。
BACKGROUND: About 15% of all pregnancies end in pregnancy loss. As most studies have focused on maternal factors little is known regarding the influence of paternal factors on the chance of successful pregnancy.
OBJECTIVE: This cohort study aims to assess the chance of biochemical pregnancy, clinical pregnancy, and live-born children in couples where the male partner has diabetes mellitus (DM).
METHODS: We performed a nationwide cohort study. Couples undergoing assisted reproductive technology treatment from 2006 to 2019 were included. The exposed cohorts comprised embryo transfers in couples with paternal type 1 DM (T1DM), type 2 DM (T2DM), or mixed type DM (TMDM). The unexposed cohort included embryo transfers in couples without paternal DM.
RESULTS: A total of 101,875 embryo transfers were included. Of these, 503 males had T1DM, 225 males had T2DM, 263 males had TMDM, and 100,884 did not have DM. For paternal T1DM, the adjusted OR for achieving a biochemical pregnancy, clinical pregnancy, and live-born child were 0.97 (95% CI 0.77-1.23), 1.08 (95% CI 0.65-1.79), and 0.75 (95% CI 0.49-1.14), respectively. For paternal T2DM, the adjusted OR for achieving a biochemical pregnancy, clinical pregnancy, and live-born child were 0.80 (95% CI 0.56;1.16), 0.67 (95% CI 0.32-1.41), and 1.03 (95% CI 0.48-2.20), respectively. For the paternal TMDM, the adjusted OR for achieving a biochemical pregnancy, clinical pregnancy and livebirth were 0.95 (95% CI 0.67-1.33), 1.31 (95% CI 0.56-2.92), and 1.19 (95% CI 0.59-2.38), respectively.
CONCLUSIONS: Paternal DM was not associated with a statistically significant decreased chance of biochemical pregnancy, clinical pregnancy, or live birth.