经典霍奇金淋巴瘤(cHL)是B细胞起源的血液恶性肿瘤。cHL中的肿瘤细胞被称为霍奇金和里德-斯特恩伯格(HRS)细胞。这篇综述概述了目前已知的miRNA-靶基因相互作用。此外,我们通过关注与cHL发病相关的过程相关的基因,确定了microRNAs(miRNAs)的其他潜在调节作用,即,B细胞表型的丧失,免疫逃避,增长支持。基于可用的谱分析研究产生cHL特异性miRNA特征。通过全面回顾现有的已验证的miRNA-靶基因相互作用的研究,提取了与cHL相关的相互作用。具有潜在关键作用的miRNA包括miR-155-5p,miR-148a-3p,miR-181a-5p,miR-200,miR-23a-3p,miR-125a/b,miR-130a-3p,miR-138和miR-143-3p,哪个目标,在其他人中,PU.1,ETS1,HLA-I,PD-L1和NF-κB成分基因。总的来说,我们对相关miRNA-靶基因相互作用提供了全面的观点,这也可以作为未来对所选miRNA在cHL发病机制中的特定作用的功能研究的基础.
Classical Hodgkin lymphoma (cHL) is a hematological malignancy of B-cell origin. The tumor cells in cHL are referred to as Hodgkin and Reed-Sternberg (HRS) cells. This review provides an overview of the currently known miRNA-target gene interactions. In addition, we pinpointed other potential regulatory roles of microRNAs (miRNAs) by focusing on genes related to processes relevant for cHL pathogenesis, i.e., loss of B-cell phenotypes, immune evasion, and growth support. A cHL-specific miRNA signature was generated based on the available profiling studies. The interactions relevant for cHL were extracted by comprehensively reviewing the existing studies on validated miRNA-target gene interactions. The miRNAs with potential critical roles included miR-155-5p, miR-148a-3p, miR-181a-5p, miR-200, miR-23a-3p, miR-125a/b, miR-130a-3p, miR-138, and miR-143-3p, which target, amongst others, PU.1, ETS1, HLA-I, PD-L1, and NF-κB component genes. Overall, we provide a comprehensive perspective on the relevant miRNA-target gene interactions which can also serve as a foundation for future functional studies into the specific roles of the selected miRNAs in cHL pathogenesis.