背景：经颈静脉肝内门体分流术（TIPS）是失代偿期肝硬化并发症患者的标准二线治疗选择，如静脉曲张出血和顽固性腹水。
目的：根据BavenoVII标准，研究TIPS治疗的失代偿期肝硬化患者是否存在再补偿。
方法：对64例因静脉曲张破裂出血或顽固性腹水而接受TIPS治疗的患者进行回顾性分析。补偿的定义参考了BavenoVII标准和先前的研究。临床事件,实验室测试,在预设的随访期内定期进行放射学检查。计算该队列中的再补偿比率。除此之外，采用单变量和多变量回归模型来确定再补偿的预测因子.
结果：在64名12个月随访的患者中，20（31%）实现了补偿。年龄[比值比（OR）：1.124;95％置信区间（CI）：1.034-1.222]和TIPS后门静脉压力梯度<12mmHg（OR：0.119;95CI：0.024-0.584）被确定为TIPS后失代偿性肝硬化患者再补偿的独立预测因子。
结论：本研究表明，近三分之一接受TIPS治疗的患者在该队列中实现了再补偿。根据我们的发现,年轻患者更有可能实现再补偿.此外,术后门静脉压力梯度降低至12mmHg以下有助于再补偿的发生。
BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPS) is the standard second-line treatment option for individuals with complications of decompensated cirrhosis, such as variceal bleeding and refractory ascites.
OBJECTIVE: To investigate whether recompensation existed in TIPS-treated patients with decompensated cirrhosis according to Baveno VII criteria.
METHODS: This retrospective analysis was performed on 64 patients who received TIPS for variceal bleeding or refractory ascites. The definition of recompensation referred to Baveno VII criteria and previous study. Clinical events, laboratory tests, and radiological examinations were regularly conducted during a preset follow-up period. The recompensation ratio in this cohort was calculated. Beyond that, univariate and multivariate regression models were conducted to identify the predictors of recompensation.
RESULTS: Of the 64 patients with a 12-mo follow-up, 20 (31%) achieved recompensation. Age [odds ratio (OR): 1.124; 95% confidence interval (CI): 1.034-1.222] and post-TIPS portal pressure gradient < 12 mmHg (OR: 0.119; 95%CI: 0.024-0.584) were identified as independent predictors of recompensation in patients with decompensated cirrhosis after TIPS.
CONCLUSIONS: The present study demonstrated that nearly one-third of the TIPS-treated patients achieved recompensation within this cohort. According to our findings, recompensation is more likely to be achieved in younger patients. In addition, postoperative portal pressure gradient reduction below 12 mmHg contributes to the occurrence of recompensation.
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