■定时营养研究饮食之间的关系,昼夜节律和新陈代谢,这可能会改变宫内代谢环境,影响婴儿脂肪质量(FM)发育,并可能增加肥胖风险。
■评估6个月时孕期营养与婴儿FM的关系。
■研究了来自OBESO队列(2017-2023)的健康孕妇和足月婴儿(n=100对)。孕产妇登记包括孕前体重指数(BMI),妊娠并发症/药物,体重增加。饮食(三次24小时召回,每个三个月1个)和睡眠时间表(第一个和第三个三个月)进行计算空腹(从最后第一餐开始的时间)评估,早餐和晚餐等待时间(醒来-早餐和晚餐-睡眠之间的分钟,分别),主餐数量/天,不吃饭(三次召回时≥一次主餐/天)和夜间吃饭(三次召回时从晚上9:00-凌晨5:59)。新生儿体重,长度,评估BMI/年龄。6个月时,婴儿FM(kg,%;空气置换体积描记术)进行了测量,并计算FM指数(FMI-kgFM/long2)。记录纯母乳喂养(EBF)。多元线性回归模型评估了慢性营养与6个月婴儿FM之间的关联。
■平均空腹为11.7±1.3小时;早餐,晚餐潜伏期分别为87.3±75.2、99.6±65.6分钟,分别。平均膳食/天为3.0±0.5。据报道,3%(n=3)的女性跳餐,35%(n=35)的女性夜间进食。大多数新生儿的BMI/年龄正常(88%,n=88)。与那些没有这样做的人相比,从事夜间饮食的母亲的婴儿FM百分比较高(p=0.019)。回归模型(R2≥0.308,p≤0.001)显示夜间进食与%FM呈正相关(B:2.7,95CI:0.32-5.16)。在分析没有并发症/药物治疗的女性时(n=80),夜间进食与更高的FM[%FM,B:3.24(95CI:0.59-5.88);kgFM,B:0.20(95CI:0.003-0.40);FMI,B:0.54(95CI:0.03-1.05)]。婴儿性别和体重(6个月)显著,而母亲肥胖,妊娠并发症/药物,奇偶校验,能量摄入,出生-BMI/年龄,EBF没有。
■母亲夜间进食与6个月婴儿肥胖增加有关。
UNASSIGNED: Chrononutrition studies the relation between diet, circadian rhythms and metabolism, which may alter the metabolic intrauterine environment, influencing infant fat-mass (FM) development and possibly increasing obesity risk.
UNASSIGNED: To evaluate the association of
chrononutrition in pregnancy and infant FM at 6 months.
UNASSIGNED: Healthy pregnant women and term-babies (n = 100pairs) from the OBESO cohort (2017-2023) were studied. Maternal registries included pregestational body-mass-index (BMI), gestational complications/medications, weight gain. Diet (three 24 h-recalls, 1 each trimester) and sleep-schedule (first and third trimesters) were evaluated computing fasting (hours from last-first meal), breakfast and dinner latencies (minutes between wake up-breakfast and dinner-sleep, respectively), number of main meals/day, meal skipping (≥1 main meal/d on three recalls) and nighttime eating (from 9:00 pm-5:59 am on three recalls). Neonatal weight, length, BMI/age were assessed. At 6 months, infant FM (kg, %; air-displacement plethysmography) was measured, and FM index (FMI-kgFM/length2) computed. Exclusive breastfeeding (EBF) was recorded. Multiple linear regression models evaluated the association between
chrononutrition and 6 month infant FM.
UNASSIGNED: Mean fasting was 11.7 ± 1.3 h; breakfast, dinner latency were 87.3 ± 75.2, 99.6 ± 65.6 min, respectively. Average meals/day were 3.0 ± 0.5. Meal skipping was reported in 3% (n = 3) of women and nighttime eating in 35% (n = 35). Most neonates had normal BMI/age (88%, n = 88). Compared to those who did not, mothers engaged in nighttime-eating had infants with higher %FM (p = 0.019). Regression models (R 2 ≥ 0.308, p ≤ 0.001) showed that nighttime eating was positively associated with %FM (B: 2.7, 95%CI: 0.32-5.16). When analyzing women without complications/medications (n = 80), nighttime eating was associated with higher FM [%FM, B: 3.24 (95%CI: 0.59-5.88); kgFM, B: 0.20 (95%CI: 0.003-0.40); FMI, B: 0.54 (95%CI: 0.03-1.05)]. Infant sex and weight (6 months) were significant, while maternal obesity, pregnancy complications/medications, parity, energy intake, birth-BMI/age, and EBF were not.
UNASSIGNED: Maternal nighttime eating is associated with higher adiposity in 6 month infants.