未经证实:卒中被认为是世界各地卫生保健中心最重要的问题之一。根据定义,存在两种类型的中风,包括缺血性中风和出血性中风。大约四分之三的中风病例是缺血性中风,这是由于几个危险因素,如高血压,肥胖,动脉粥样硬化,糖尿病,骨关节炎,和炎症反应。近年来,感染性疾病已成为缺血性卒中的新危险因素。鉴于问题的重要性,一些引起慢性感染的细菌,尤其是衣原体肺炎,幽门螺杆菌,支原体肺炎,结核分枝杆菌,和柯西拉·伯内蒂被考虑过。
未经评估:在本荟萃分析中,我们回顾了50项病例对照研究,并评估了细菌感染与缺血性卒中发生的可能相关性.
UNASSIGNED:我们分析了一些嵌套病例对照研究中的33,978名参与者的信息,并最终表明细菌感染可增加缺血性卒中的风险。我们的结果表明细菌感染显著增加缺血性卒中的风险(OR:1.704;1.57-1.84,95%CIs;p值=0.01)。
未经评估:在此荟萃分析中,观察到三种细菌如肺炎衣原体感染之间存在显著关系,幽门螺杆菌,和结核分枝杆菌与缺血性中风的发生。此外,由于β2-糖蛋白-I中的TLRVYK结构域与各种微生物中的TLRVYK肽之间的相似性,产生的针对病原体的抗体与β2-糖蛋白-I相互作用,因此,交叉反应现象增加了感染性疾病和缺血性卒中之间的正相关关系。
UNASSIGNED: Stroke is considered as one of the most important concerns in health care centers around the world. By definition there are two types of stroke including ischemic stroke and hemorrhagic stroke. Approximately three-quarters of stroke cases are ischemic strokes, which occur due to several risk factors such as hypertension, obesity, atherosclerosis, diabetes mellitus, osteoarthritis, and inflammatory responses. In recent years, infectious diseases have noticed as a new risk factor for ischemic stroke. Given the importance of the issue, some bacteria that cause chronic infections, especially Chlamydia pneumonia, Helicobacter pylori, Mycoplasma pneumonia, Mycobacterium tuberculosis, and Coxiella burnetii have been considered.
UNASSIGNED: In the present meta-analysis, we reviewed 50 case-control studies and assessed the possible association of bacterial infections with the occurrence of ischemic stroke.
UNASSIGNED: We analyzed the information of 33,978 participants in several nested case-control studies, and ultimately showed that bacterial infections could increase the risk of ischemic stroke. Our results suggest that bacterial infections significantly increase in the risk of ischemic stroke (OR: 1.704; 1.57-1.84 with 95% CIs; p value = 0.01).
UNASSIGNED: In this meta-analysis, a significant relationship was observed between infection by three bacteria such as C. pneumoniae, H. pylori, and M. tuberculosis with the occurrence of ischemic stroke. Furthermore, due to the similarity between TLRVYK domain in β2-glycoprotein-I and TLRVYK peptide in various of microorganisms, produced antibodies against pathogens interact with β2-glycoprotein-I, hence the cross-reaction phenomenon increases the positive relationship between infectious diseases and ischemic stroke.