目的:评估儿童时期背景和纺锤体频段的半球间相干性(ICo)的演变,并将其用于识别call体发育不全(CCd)的个体。
方法:以0.25至15岁的儿童为中心的队列,由13名患有CCd的儿童和164名没有CCd的儿童组成,被分析。背景活动的ICo(ICOBckgrdA),睡眠主轴(ICOspindles),并计算了它们的总和(sICO)。年龄的影响,性别,并评估了ICO上的CC状态,sICO被用来区分有或没有CCd的儿童。
结果:ICOBckgrdA,ICOspindles和sICO随年龄显著增加,性别无任何影响(p<10-4),在两组中。不同ICo的回归方程较强,调整后的R2值分别为0.54、0.35和0.57。与没有CCd的儿童相比,有CCd的儿童的ICo较低(所有比较的p<10-4)。使用sICO预测CCd的精确召回曲线下面积为0.992,灵敏度为98.9%,特异性为87.5%。
结论:纺锤体的ICo和背景活动与大脑成熟平行发展,并取决于call体的完整性。sICO可能是筛查半球间功能障碍儿童的有效诊断生物标志物。
OBJECTIVE: To evaluate the evolution of interhemispheric coherences (ICo) in background and spindle frequency bands during childhood and use it to identify individuals with corpus callosum dysgenesis (CCd).
METHODS: A monocentric cohort of children aged from 0.25 to 15 years old, consisting of 13 children with CCd and 164 without, was analyzed. The ICo of background activity (ICOBckgrdA), sleep spindles (ICOspindles), and their sum (sICO) were calculated. The impact of age, gender, and CC status on the ICo was evaluated, and the sICO was used to discriminate children with or without CCd.
RESULTS: ICOBckgrdA, ICOspindles and sICO increased significantly with age without any effect of gender (p < 10-4), in both groups. The regression equations of the different ICo were stronger, with adjusted R2 values of 0.54, 0.35, and 0.57, respectively. The ICo was lower in children with CCd compared to those without CCd (p < 10-4 for all comparisons). The area under the precision recall curves for predicting CCd using sICO was 0.992 with 98.9 % sensitivity and 87.5 % specificity.
CONCLUSIONS: ICo of spindles and background activity evolve in parallel to brain maturation and depends on the integrity of the corpus callosum. sICO could be an effective diagnostic biomarker for screening children with interhemispheric dysfunction.