查尔酮是一种简单的天然存在的α,具有生物学重要性的β-不饱和酮,这也可以很容易地合成在实验室通过两个芳香支架之间的反应。在植物中,查耳酮是作为不同骨架的多酚化合物而出现的,它们是传统医学实践多年的生物活性分子。已经开发了基于查尔酮的铅分子,具有不同的潜力,如抗菌,抗病毒,抗炎,抗癌,抗氧化剂,抗糖尿病药,抗高尿酸血症,和抗溃疡作用。Chalcones贡献了相当多的片段,以提供具有靶向各种疾病的治疗用途的重要杂环分子。这些特征使查尔酮成为研究人员感兴趣的话题,并吸引了对这种广泛适用结构的研究。这篇综述强调了对合成进行的广泛探索,生物转化,化学反应,杂交,和查尔酮的药理潜力,并旨在提供广泛的,彻底,并对其重要性进行批判性审查,强调它们的属性,化学,和生物医学应用,以促进对药物化学中这种潜在支架的未来研究。
Chalcone is a simple naturally occurring α,β-unsaturated ketone with biological importance, which can also be easily synthesized in laboratories by reaction between two aromatic scaffolds. In plants, chalcones occur as polyphenolic compounds of different frameworks which are bioactive molecules that have been in traditional medicinal practice for many years. Chalcone-based lead molecules have been developed, possessing varied potentials such as antimicrobial, antiviral, anti-inflammatory, anticancer, anti-oxidant, antidiabetic, antihyperurecemic, and anti-ulcer effects. Chalcones contribute considerable fragments to give important heterocyclic molecules with therapeutic utilities targeting various diseases. These characteristic features have made chalcone a topic of interest among researchers and have attracted investigations into this widely applicable structure. This review highlights the extensive exploration carried out on the synthesis, biotransformations, chemical reactions, hybridization, and pharmacological potentials of chalcones, and aims to provide an extensive, thorough, and critical review of their importance, with emphasis on their properties, chemistry, and biomedical applications to boost future investigations into this potential scaffold in medicinal chemistry.