Chemical compositions

化学成分
  • 文章类型: Journal Article
    LumnitzeraracemosaWilld是一种药用物种,支持某些条件的治疗。这是对LumnitzeraracemosaWilld树皮精油的化学组成和抗菌活性的首次研究。该精油通过加氢蒸馏法提取,并通过气相色谱法(GC)进行分析,和气相色谱与质谱联用(GC-MS)。结果表明,精油含有二十四种化合物,其中主要是棕榈酸,壬烷,和庚烷。精油对铜绿假单胞菌的抗菌活性,和金黄色葡萄球菌的抑制区范围约为8.4-17.5毫米。这项研究提高了对组成的理解,外消旋乳杆菌的抗菌活性,拓展了其在医学领域的潜在应用。
    Lumnitzera racemosa Willd is a medicinal species that supports the treatment of certain conditions. This is the first study on the chemical composition and antimicrobial activities of the essential oil from Lumnitzera racemosa Willd bark. This essential oil was extracted by the hydrodistillation method and analysed by gas chromatography (GC), and gas chromatography coupled with mass spectrometry (GC-MS). The results showed that the essential oil contains twenty-four compounds, the main of which are palmitic acid, nonacosane, and heptacosane. The antimicrobial activities of the essential oil against Pseudomonas aeruginosa, and Staphylococcus aureus had inhibition zones ranging from approximately 8.4-17.5 mm. This study has enhanced the understanding of the composition, and antimicrobial activities of L. racemosa and expanded its potential applications in the medical field.
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  • 文章类型: Journal Article
    覆盆子用于食品和药品,但尚未引起广泛关注。在本文中,原始植物覆盆子的化学成分。R.chingii是2017年入选的新“哲八味”药材之一。“哲八味”是指浙江省的八种道地药材。化学成分,药理作用,processing,并对其应用进行了综述,为其进一步发展提供参考。近年来的相关文献被收集在中国知网等数据库中,WebofScience,Elsevier,PubMed,和X-Mol,使用“树莓”,\"Rubuschingii\",“传统使用”,“化学成分”,“药理学”,等。作为单独或组合的关键字。药理活性综述表明,树莓的药理活性之间的关系还不够深入。应在此方向上开展更深入的研究,探讨其活性成分的作用机理,为树莓产业的进一步发展提供有效参考。在未来,随着更多研究人员的参与,预计将开发基于覆盆子的创新药物来治疗疾病。
    Raspberries are used for both food and medicine, but it has not yet attracted widespread attention. In this paper, the chemical constituen of the original plant raspberry. R. chingii is one of the new \"Zhe Bawei\" medicinal materials selected in 2017. \"Zhe Bawei\" refers to eight kinds of genuine medicinal materials in Zhejiang Province. The chemical constituents, pharmacological effects, processing, and application of Rubus chingii Hu were reviewed to provide a reference for its further development. Relevant literature in recent years was collected in databases such as China Knowledge Network, Web of Science, Elsevier, PubMed, and X-Mol, using \"raspberry\", \"Rubus chingii\", \"traditional use\", \"chemical composition\", \"pharmacology\", etc. as keywords individually or in combination. The summary of pharmacological activities shows that the relationship between the pharmacological activities of raspberry is still not deep enough. More in-depth research should be carried out in this direction to explore the mechanism of action of its active ingredients and provide effective reference for the further development of the raspberry industry. In the future, with the participation of more researchers, it is expected to develop innovative drugs based on raspberry for the treatment of diseases.
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  • 文章类型: Journal Article
    众所周知,微生物群落在维持生态平衡中起着重要作用,可以作为评估环境污染的指标。大量研究表明,空气污染可以改变微生物群落的结构,这可能会增加健康风险。然而,在健康风险评估方面,微生物群落与空气污染引起的颗粒物(PM)之间的关系尚不清楚。本研究旨在验证PM化学成分对微生物群落的影响,并评估相关的健康风险。我们的结果,基于相似性分析,结果表明,微生物群落的稳定性结构相似性大于73%。此外,微生物群落的丰富度和多样性的改变与PM化学成分显着相关。挥发性有机化合物(VOCs)和多环芳烃(PAHs)在不同的环境变量中对微生物群落产生积极影响。此外,在羟基自由基(·OH)和微生物群落的丰富度之间观察到更强的线性相关。所有估计的PM化学成分的健康风险,在不同的环境变量下计算,大大超过可接受水平49倍以上。Cr和1,2-二溴乙烷表现出非致癌和致癌风险的双重不利影响。总的来说,这项研究提供了对PM驱动的微生物群落变异性的基本机制的见解,这可能支持PM化学成分在大气环境中微生物风险中的关键作用。
    Microbial communities are known to play an important role in maintaining ecological balance and can be used as an indicator for assessing environmental pollution. Numerous studies have revealed that air pollution can alter the structure of microbial communities, which may increase health risks. Nevertheless, the relationships between microbial communities and particulate matter (PM) caused by air pollution in terms of health risk assessment are not well understood. This study aimed to validate the influences of PM chemical compositions on microbial communities and assess the associated health risks. Our results, based on similarity analysis, revealed that the stability structure of the microbial communities had a similarity greater than 73%. In addition, the altered richness and diversity of microbial communities were significantly associated with PM chemical compositions. Volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) exerted a positive influence on microbial communities in different environmental variables. Additionally, a stronger linear correlation was observed between hydroxyl radicals (·OH) and the richness of microbial communities. All estimated health risks from PM chemical compositions, calculated under different environmental variables, significantly exceeded the acceptable level by a factor of more than 49. Cr and 1,2-Dibromoethane displayed dual adverse effects of non-carcinogenic and carcinogenic risks. Overall, the study provides insights into the fundamental mechanisms of the variability in microbial communities driven by PM, which may support the crucial role of PM chemical compositions in the risk of microorganisms in the atmospheric environment.
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  • 文章类型: Journal Article
    脑心通胶囊(NXT),一种著名的中药(TCM)配方,在中国已经广泛应用了30多年。几十年来,越来越多的证据证明NXT治疗心脑血管疾病(CCVD)的疗效和安全性令人满意。研究不断进行,虽然这种日益增长的NXT最新知识尚未得到正确解释和全面总结。因此,我们系统地回顾了NXT研究的进展,从它的化学成分,质量控制,药代动力学,其深刻的药理活性及其在CCVD中的临床应用。此外,我们进一步提出了其未来前景的具体挑战:1)精确阐明单一化合物在复杂混合物中的生物活性;2)评估NXT特征组分在临床研究中的药代动力学行为,尤其是CCVD患者的药物相互作用;3)通过整合多组学技术,探索和验证其多靶点作用机制;4)通过开展大规模、多中心随机对照试验。简而言之,本文旨在理顺中医现代化的范式,这有助于将NXT作为中国智慧纳入CCVD治疗的先进干预策略。
    Naoxintong Capsule (NXT), a renowned traditional Chinese medicine (TCM) formulation, has been broadly applied in China for more than 30 years. Over decades, accumulating evidences have proven satisfactory efficacy and safety of NXT in treating cardiovascular and cerebrovascular diseases (CCVD). Studies have been conducted unceasingly, while this growing latest knowledge of NXT has not yet been interpreted properly and summarized comprehensively. Hence, we systematically review the advancements in NXT research, from its chemical constituents, quality control, pharmacokinetics, to its profound pharmacological activities as well as its clinical applications in CCVD. Moreover, we further propose specific challenges for its future perspectives: 1) to precisely clarify bioactivities of single compound in complicated mixtures; 2) to evaluate the pharmacokinetic behaviors of NXT feature components in clinical studies, especially drug-drug interactions in CCVD patients; 3) to explore and validate its multi-target mechanisms by integrating multi-omics technologies; 4) to re-evaluate the safety and efficacy of NXT by carrying out large-scale, multicenter randomized controlled trials. In brief, this review aims to straighten out a paradigm for TCM modernization, which help to contribute NXT as a piece of Chinese Wisdom into the advanced intervention strategy for CCVD therapy.
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  • 文章类型: Journal Article
    在细颗粒物(PM2.5)和臭氧(O3)之间的颗粒-臭氧协同关系(PO)方面存在相当大的学术兴趣。使用各种天气天气模式(SWPs),我们定量评估了PO的变化,这与制定旨在控制空气中复杂污染的政策有关。首先,基于2018年3月至2019年2月的1年抽样数据,采用平方和技术(SS)对长江三角洲(YRD)进行SWPs分类.在YRD地区可以找到五个优势SWP,包括低于SWP1的阿留申低点(发生在今年的45%),SWP2下的热带气旋(21%),热带气旋和西太平洋副热带高压(WPSH)低于SWP3(15.4%),SWP4下的WPSH(6.9%),和SWP5下的大陆高压(3.1%)。PM2.5和O3浓度之间的“跷跷板”现象表现出明显的空间异质性,受气象机制的影响。第二,采用多元线性回归(MLR)模型和偏相关(PCOR)分析来量化主要成分和气象因素对PO的影响。气象变量只能共同解释PM2.5变化的33.0%,但O3为58.0%。O3在低浓度的PM2.5中相互促进,但在高浓度的PM2.5中受到抑制。高相对湿度(RH)有利于PM2.5二次组分的生成,增强了气溶胶的辐射效应和PO的负相关。此外,应注意评估前体水平的综合影响,天气,以及对粒子-臭氧复合污染的化学反应。夏季应加强O3污染物的控制,而重点应该是减少冬季PM2.5污染物。防治措施需要反映天气状况和污染特征的差异,重点关注RH和PM2.5的次要成分。
    There is considerable academic interest in the particle-ozone synergistic relationship (PO) between fine particulate matter (PM2.5) and ozone (O3). Using various synoptic weather patterns (SWPs), we quantitatively assessed the variations in the PO, which is relevant to formulating policies aimed at controlling complex pollution in the air. First, based on one-year sampling data from March 2018 to February 2019, the SWPs classification of the Yangtze River Delta (YRD) was conducted using the sum-of-squares technique (SS). Five dominant SWPs can be found in the YRD region, including the Aleutian low under SWP1 (occurring 45 % of the year), a tropical cyclone under SWP2 (21 %), the tropical cyclone and western Pacific Subtropical High (WPSH) under SWP3 (15.4 %), the WPSH under SWP4 (6.9 %), and a continental high pressure under SWP5 (3.1 %). The phenomenon of a \"seesaw\" between PM2.5 and O3 concentrations exhibited significant spatial heterogeneity, which was influenced by meteorological mechanisms. Second, the multi-linear regression (MLR) model and the partial correlation (PCOR) analysis were employed to quantify the effects of dominant components and meteorological factors on the PO. Meteorological variables could collectively explain only 33.0 % of the PM2.5 variations, but 58.0 % for O3. O3 promoted each other with low concentrations of PM2.5 but was inhibited by high concentrations of PM2.5. High relative humidity (RH) was conducive to the generation of PM2.5 secondary components and enhanced the radiative effects of aerosols and the negative correlation of PO. In addition, attention should be paid to assessing the combined effects of precursor levels, weather, and chemical reactions on the particle-ozone complex pollution. The control of O3 pollutants should be intensified in summer, while the focus should be on reducing PM2.5 pollutants in winter. Prevention and control measures need to reflect the differences in weather conditions and pollution characteristics, with a focus on RH and secondary components of PM2.5.
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  • 文章类型: Journal Article
    在中国,山茶植物广泛用于减少特应性皮炎和炎症相关疾病,但其保护机制尚不清楚。这项研究调查了抗过敏性皮炎,5种山茶的抗氧化和抗炎作用及其潜在机制,包括山茶花,山茶。KuchaChang,小山茶花,茶花长,还有C.assamicaM.Chang.从5种山茶提取物中检测到总共约110种化学成分。HE(苏木精-伊红)染色和甲苯胺蓝染色测定模型小鼠皮肤肥大细胞浸润水平,免疫组织化学法检测白细胞介素-1β(IL-1β)和神经生长因子的水平。5种山茶叶提取物具有组胺诱导的过敏性皮炎。脂多糖诱导的小鼠巨噬细胞RAW264.7炎症模型被发现分泌NF-κB因子,如免疫荧光所示,并检测活性氧分泌及相关细胞因子水平。结果表明,山茶花5种茶提取物具有抵抗细胞氧化应激的能力。此外,纤维连接蛋白(FN)和白细胞介素-6(IL-6)等细胞炎性细胞因子的检测结果表明山茶的五种茶提取物具有抗炎作用。因此,这表明五种山茶可能具有抑制过敏反应的特性,氧化应激,和炎症,并可能被证明对治疗过敏有益。
    In China, Camellia plants are widely used to reduce atopic dermatitis and inflammation-related diseases, but their protective mechanisms remain unclear. This study investigated the anti-allergic dermatitis, anti-oxidation and anti-inflammation effect and underlying mechanism of five Camellia species, including Camellia ptilophylla Chang, Camellia assamica Chang var. Kucha Chang, Camellia parvisepala Chang, Camellia arborescens Chang, and C. assamica M. Chang. A total of about 110 chemical compositions were detected from five Camellia teas extracts. The level of mast cell infiltration in the model mice skin was determined by HE (Hematoxylin and eosin) staining and toluidine blue staining, and the level of interleukin-1β (IL-1β) and nerve growth factor was detected by immunohistochemistry. The five Camellia tea leaf extracts have histamine-induced allergic dermatitis. Lipopolysaccharide (Lipopolysaccharide)-induced murine macrophage RAW264.7 inflammation model was found to secrete NF-κB factor, as shown by immunofluorescence, and reactive oxygen species secretion and related cytokine levels were detected. The results suggested that Camellia\'s five tea extracts had the ability to resist cellular oxidative stress. In addition, the results of cell inflammatory cytokines including fibronectin (FN) and interleukin-6 (IL-6) suggested that the five tea extracts of Camellia had anti-inflammatory effects. Therefore, it is suggested that five Camellia teas may possess inhibitory properties against allergic reactions, oxidative stress, and inflammation, and may prove beneficial in the treatment of allergies.
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  • 文章类型: Journal Article
    预期纳米塑料在各种环境隔室中普遍存在。然而,分析方法的挑战阻碍了我们对与特定纳米塑料特性(如尺寸和化学成分)相关的风险的理解,以及纳米塑料和微生物之间的相互作用。在这项研究中,我们应用适合目的的分析方法和技术来了解纳米塑料化学成分如何影响它们与从活性污泥中收集的细菌的相互作用。当暴露于聚苯乙烯(PS)和聚氯乙烯(PVC)纳米塑料5天时,纳米塑料附着在细菌上。具体来说,在第1天,PS纳米塑料明显优于尺寸和形状相似的PVC,可能是由于化学成分的差异。5天后,附着在细菌上的纳米塑料大幅减少,提示细菌防御机制可能会随着时间的推移减少颗粒附着。总体细菌群落结构表现出高度的恢复力。这种复原力突出了微生物群落维持其结构的能力,尽管有纳米塑料压力,一致的阿尔法多样性证明了这一点,PCoA,和PERMANOVA结果。了解这些机制对于评估纳米塑料的命运和环境影响至关重要。
    Nanoplastics are anticipated to be ubiquitous in various environmental compartments. However, challenges in analytical methods hinder our understanding of risks related to specific nanplastics characteristics such as size and chemical compositions, and interactions between nanoplastics and microorganisms. In this study, we applied fit-for-purpose analytical methods and techniques to understand how nanoplastic chemical composition influences their interaction with bacteria collected from activated sludge. When exposed to polystyrene (PS) and polyvinyl chloride (PVC) nanoplastics for 5 days, the nanoplastics attached to the bacteria. Specifically, on day 1, there was a significant predominance of PS nanoplastics over PVC ones of similar size and shape, possibly due to differences in their chemical composition. After 5 days, there is a substantial decrease in nanoplastics attached to bacteria, suggesting bacterial defence mechanisms may reduce particles attachment over time. The overall bacterial community structure demonstrated a high degree of resilience. This resilience highlights the ability of microbial communities to maintain their structure despite nanoplastic stressors, as evidenced by consistent alpha diversity, PCoA, and PERMANOVA results. Understanding these mechanisms is crucial for assessing nanoplastic fate and thus environmental impacts.
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  • 文章类型: Journal Article
    咖啡质量是一个复杂的属性,受多种因素的影响,包括采后处理方法。这项研究的目的是调查咖啡加工方法对咖啡质量的影响(生,杯子,和生化化妆)在Jimma,代表中部地区。为Jimma农业研究中心收集咖啡样品,并用三种方法(洗涤,半洗涤和干燥过程)。结果表明,洗涤咖啡豆得分最高的颜色(13.43)和气味[10]得分比其他处理方法。因此,对于在Jimma中洗涤的咖啡,报告了统计学上最好的原始质量评分(35.57%)。然而,杯的质量属性不受处理方法的显著影响。在研究的化学成分中,脂质受加工方法的影响显着,半洗和洗涤咖啡豆的最高脂质分别为13.74和13.17g/100g。一般来说,洗涤和半洗咖啡在豆色和气味质量方面是优选的。发现杯子质量属性和化学成分之间存在相关性。然而,有必要进一步研究该地区咖啡加工方法的可及性和经济性。
    Coffee quality is a complex attribute influenced by a variety of factors, including postharvest processing methods. The goal of this study was to investigate the impact of coffee processing methods on coffee quality (raw, cup, and biochemical makeup) in Jimma, which represents the midland areas. Coffee samples were collected for Jimma agricultural research center and processed with three methods (washed, Semi-washed and dry process). The result indicated that washed coffee beans scored significantly the highest color (13.43) and odor [10] score than the other processing methods. The statistically best raw quality score (35.57 %) was therefore reported for washed coffee in Jimma. Cup quality attributes however were not significantly affected by processing methods. Among chemical composition studied, lipid was significantly affected by processing methods and highest lipid 13.74 and 13.17 g/100g was reported for semi-washed and washed coffee beans respectively. Generally, washed and semi-washed coffee were preferable in terms of bean color and odor quality. Correlations were found among cup quality attributes and chemical compositions. However, further research into the accessibility and economics of coffee processing methods in the area is necessary.
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  • 文章类型: Journal Article
    韧皮纤维被定义为从各种植物家族的韧皮纤维的外细胞层获得的那些。它们正在纺织应用中得到应用,并被广泛用作绿色复合材料的增强材料,因为韧皮纤维被认为是“可持续的”。由于韧皮纤维的可再生和可生物降解的性质,全世界对韧皮纤维的需求不断增长。韧皮纤维主要由纤维素组成,这可能会考虑到日益增长的技术,韧皮纤维的收获和提取过程最常用于生产具有适当质量的纤维,适用于现代社会中现代男女的日常生活。这篇综述论文着眼于天然纤维的许多方面,专注于植物韧皮纤维,包括它们对史前和历史社会的影响。这篇综述表明,韧皮纤维在许多应用中与人造纤维相比具有竞争力,但是机械性能和低韧性的可变性可能会限制它们在高强度复合材料中的使用,特别是在航空航天领域,汽车,包装,建筑业,绝缘,E复合材料(生态复合材料),目前正在探索土工布和许多其他应用。考虑到,韧皮纤维的重要特征包括物理,机械,和化学性质。这使得韧皮纤维成为用作热固性/热塑性聚合物基质中的增强剂的最重要的植物纤维类别之一。以及韧皮纤维作为增强材料对ECO复合材料性能的影响,绿色复合材料,生物复合材料,轻质复合材料。韧皮纤维在可持续发展中起着重要作用,保护环境的健康,下一代的幸福,甚至是当代世界男女的日常生活。
    Bast fibers are defined as those obtained from the outer cell layers of the bast of various plant families. They are finding use in textile applications and are widely used as reinforcements for green composites, as bast fibers are perceived as \"sustainable\". There is a growing demand for bast fibers across the world due to their renewable and biodegradable nature. The bast fibers are mainly composed of cellulose, which potentially considers the growing techniques, harvesting and extraction processes of bast fibers most used to produce fibers with appropriate quality to apply in the daily lives of modern men and women in contemporary society. This review paper looks at many aspects of natural fibers, with a focus on plant bast fibers, including their impact on prehistoric and historical society. This review shows that bast fibers are competitive compared to man-made fibers in many applications, but variability in mechanical properties and low tenacity may limit their use in high-strengthh composites and extend to, particularly in aerospace, automotive, packaging, building industries, insulation, E-composites (Eco composites), geotextiles and many other applications are currently being explored. Considering, important characteristics of bast fibers include physical, mechanical, and chemical properties. This makes bast fibers one of the most important classes of plant fibers to use as reinforcing agents in thermosetting/thermoplastic polymer matrices. And the effect of bast fibers as reinforcement in the properties of ECO-composites, GREEN-composites, BIO-composites, lightweight composites. Bast fibers play an important role in sustainability, the preservation of the health of the environment, the well-being of the next generation, and even the daily lives of men and women in the contemporary world.
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  • 文章类型: Journal Article
    紫罗兰(L.)O.E.Schulz(十字花科)在我国分布广泛、数量丰富,在观赏、油,生态学,觅食,和食物。最近的研究表明,紫草的主要成分包括类黄酮,生物碱,苯丙素类化合物,酚酸,萜类化合物,等。,具有抗氧化等药理活性,抗辐射,抗肿瘤,肝脏保护,抗铁凋亡,抗炎,和抗菌。在本文中,营养价值,化学成分,药理活性,通过查阅国内外相关文献,总结了紫草的应用价值,为进一步研究提供参考,发展,和未来紫草的利用。
    Orychophragmus violaceus (L.) O. E. Schulz (Brassicaceae) is widely distributed and plentiful in China and has been widely used for its application in ornamental, oil, ecology, foraging, and food. Recent studies have revealed that the main components of Orychophragmus violaceus include flavonoids, alkaloids, phenylpropanoids, phenolic acids, terpenoids, etc., which have pharmacological activities such as antioxidation, antiradiation, antitumor, hepatic protection, antiferroptosis, anti-inflammatory, and antibacterial. In this paper, the nutritional value, chemical compositions, pharmacological activity, and application value of Orychophragmus violaceus are summarized by referring to the relevant domestic and international literature to provide a reference for further research, development, and utilization of Orychophragmus violaceus in the future.
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