背景:创伤后远端肢体伤口会引起不适,并通过第二意图逐渐愈合。Tri-Solfen(盐酸利多卡因,盐酸布比卡因,肾上腺素酒石酸和西曲米特[LBAC])在羔羊中产生有效的术后皮肤镇痛,小牛和小猪;然而,它对马匹伤口的影响是未知的。
方法:抗伤害作用,用机械阈值(MT)测量,在10匹马的20×20mm远端肢体伤口上研究了LBAC与生理盐水相比的伤口愈合影响。在第0天受伤后,每天施用一次治疗,持续7天。在治疗后第1、2和3天测量机械阈值。观察愈合25天。
结果:受伤后立即局部应用LBAC,并在24小时后再次应用,创伤后第一天的平均MT增加了3牛顿。然而,在第2天或第3天未观察到抗伤害作用.与盐水相比,用LBAC治疗对伤口愈合没有不利影响。
结论:方法学差异排除了研究之间的绝对MT比较。实验设计不包括污染的或天然存在的伤口的模型。
结论:LBAC应用于未污染的手术伤口时,可以提供早期的抗伤害作用,而不会损害愈合。
BACKGROUND: Post-traumatic distal limb wounds cause discomfort and heal gradually by second intention. The topical application of Tri-Solfen (lidocaine hydrochloride, bupivacaine hydrochloride, adrenaline acid tartrate and cetrimide [LBAC]) produces effective postsurgical cutaneous analgesia in lambs, calves and piglets; however, its effect on wounds in horses is unknown.
METHODS: The antinociceptive effect, measured by mechanical threshold (MT), and the wound healing impacts of LBAC compared with saline were investigated on surgically created 20 × 20 mm distal limb wounds in 10 horses. Treatment was applied once daily for 7 days following wounding on day 0. Mechanical thresholds were measured after treatment on days 1, 2 and 3. Healing was observed for 25 days.
RESULTS: The topical application of LBAC immediately following wounding and its reapplication 24 hours later increased the average MT on the first post-traumatic day by 3 Newtons. However, no antinociceptive benefit was observed on days 2 or 3. Treatment with LBAC did not adversely affect wound healing when compared with saline.
CONCLUSIONS: Methodological differences preclude absolute MT comparisons between studies. The experimental design did not include a model of contaminated or naturally occurring wounds.
CONCLUSIONS: LBAC may provide an early antinociceptive benefit when applied to uncontaminated surgically created wounds without compromising healing.