背景:疾病不和谐的双胞胎是匹配病例对照研究的优秀受试者,因为它们可以控制混杂因素,如年龄,性别,遗传背景,宫内和早期环境因素。研究设计:横断面研究。
方法:对所有参与者进行既往病史记录和体格检查。采取空腹静脉血样本以测量空腹血糖(FBG)和血脂水平。ACE模型,结构方程模型,用于评估遗传力。
结果:这项研究包括710对双胞胎(210个单卵和500个双卵),年龄在2至52岁之间(平均年龄:11.67±10.71岁)。这项研究是使用2017年伊斯法罕双胞胎登记处(ITR)的参与者进行的。结果显示,在儿童早期(2-6岁),高度,体重,和体重指数(BMI)受共同环境因素的影响(76%,75%,73%,分别)。在儿童晚期(7-12岁),臀围,腰围(WC),和低密度脂蛋白(LDL)胆固醇被发现是高度可遗传的(90%,76%,64%,分别)。在青少年中,身高(94%),颈围(85%),LDL-胆固醇(81%),WC(70%),甘油三酯(69%),体重(68%),BMI(65%)均为高度或中度遗传。在成年双胞胎中,臂围(97%),体重(86%),BMI(82%),颈围(81%)具有高度遗传性。
结论:这项研究表明,遗传和环境因素都在影响个体生命不同阶段的过程中发挥作用。值得注意的是,虽然某些特征如肥胖在童年时期具有很高的遗传力,随着个体过渡到成年,它们的遗传力趋于下降。
BACKGROUND: Disease-discordant twins are excellent subjects for matched case-control studies as they allow for the control of confounding factors such as age, gender, genetic background, and intrauterine and early environment factors. Study design: A cross-sectional study.
METHODS: Past medical history documentation and physical examination were conducted for all participants. Fasting venous blood samples were taken to measure fasting blood glucose (FBG) and lipid levels. The ACE model, a structural equation model, was used to assess heritability.
RESULTS: This study included 710 twin pairs (210 monozygotic and 500 dizygotic) ranging in age from 2 to 52 years (mean age: 11.67±10.71 years). The study was conducted using participants from the Isfahan Twin Registry (ITR) in 2017. Results showed that in early childhood (2-6 years), height, weight, and body mass index (BMI) were influenced by shared environmental factors (76%, 75%, and 73%, respectively). In late childhood (7-12 years), hip circumference, waist circumference (WC), and low-density lipoprotein (LDL) cholesterol were found to be highly heritable (90%, 76%, and 64%, respectively). In adolescents, height (94%), neck circumference (85%), LDL-cholesterol (81%), WC (70%), triglycerides (69%), weight (68%), and BMI (65%) were all found to be highly or moderately heritable. In adult twins, arm circumference (97%), weight (86%), BMI (82%), and neck circumference (81%) were highly heritable.
CONCLUSIONS: This study demonstrates that both genetic and environmental factors play a role in influencing individuals at different stages of their lives. Notably, while certain traits such as obesity have a high heritability during childhood, their heritability tends to decrease as individuals transition into adulthood.