■心脏再生医学近年来获得了极大的关注,已知整合素在介导心脏发育和修复中起关键作用,尤其是在心肌梗死(MI)损伤后。鉴于该领域的广泛研究历史和跨学科性质,相关主题的定量回顾性分析和可视化是必要的。
■我们对有关心脏整联蛋白粘附复合物(IAC)的已发表论文进行了科学计量分析,包括对年度出版物的分析,学科演变,关键字共现,和文学共同引用。
■在过去的20年中,总共有2664种出版物被收录。美国是这项研究的最大贡献者,并在全球领导这一研究领域。《循环研究》杂志吸引了数量最多的高质量出版物。心脏修复/再生疗法中IAC的研究涉及多个学科,特别是在材料科学和发育生物学领域。研究前沿的关键词以Tenasin-C(2019-2023)和炎症(2020-2023)为代表。
■整合素是在生物发育和组织再生方面具有持续热情的主题。细胞蛋白和细胞外基质(ECM)的非蛋白组分在调节基质结构和功能方面的迅速出现的作用可能是未来进一步的突破口;IACs的出现及其下游分子信号在心脏修复中的作用也备受关注,如诱导心脏增殖,分化,成熟,和新陈代谢,成纤维细胞活化,和炎症调节。
UNASSIGNED: Cardiac regenerative medicine has gained significant attention in recent years, and integrins are known to play a critical role in mediating cardiac development and repair, especially after an injury from the myocardial infarction (MI). Given the extensive research history and interdisciplinary nature of this field, a quantitative retrospective analysis and visualization of related topics is necessary.
UNASSIGNED: We performed a scientometric analysis of published papers on cardiac integrin adhesion complexes (IACs), including analysis of annual publications, disciplinary evolution, keyword co-occurrence, and literature co-citation.
UNASSIGNED: A total of 2,664 publications were finally included in the past 20 years. The United States is the largest contributor to the study and is leading this area of research globally. The journal Circulation Research attracts the largest number of high-quality publications. The study of IACs in cardiac repair/regenerative therapies involves multiple disciplines, particularly in materials science and developmental biology. Keywords of research frontiers were represented by Tenasin-C (2019-2023) and inflammation (2020-2023).
UNASSIGNED: Integrins are topics with ongoing enthusiasm in biological development and tissue regeneration. The rapidly emerging role of matricellular proteins and non-protein components of the extracellular matrix (ECM) in regulating matrix structure and function may be a further breakthrough point in the future; the emerging role of IACs and their downstream molecular signaling in cardiac repair are also of great interest, such as induction of cardiac proliferation, differentiation, maturation, and metabolism, fibroblast activation, and inflammatory modulation.