利什曼病是由利什曼原虫引起的人畜共患疾病。,影响多个系统和器官。虽然血液学和生化特征并不能明确诊断,最近的研究已经确定了中性粒细胞与淋巴细胞的比率(NLR),血小板与淋巴细胞比率(PLR)和全身免疫炎症指数(SII)可作为危重患者和犬患者发病率和死亡率的预测因子。这项研究检查了100只诊断为利什曼病的狗,由国际肾脏权益协会(IRIS)第1-4阶段分类。此外,根据存活时间少于或多于1年(L1Y和G1Y)来划分狗。对照组由43只狗组成。NLR随着疾病的进展而增加(IRIS1-4),与对照组(2,37±2,08)IRIS3和4(分别为4,59±13,39和6,99±12,86)相比,差异有统计学意义(P<0.05),G1Y和L1Y(分别为3,60±4,02和4,87±5,82)。SII的显着变化仅在短期幸存者(L1Y951,93±1402)和晚期肾脏疾病病例(IRIS4阶段1073,68±1901,09)中明显。相反,PLR基本保持不变。总之,这些结果表明,中性粒细胞与淋巴细胞比值(NLR)和全身免疫炎症指数(SII)可作为评估诊断为利什曼病的犬的疾病进展和预后的潜在标志物.
Leishmaniasis is a zoonotic disease caused by Leishmania spp., impacts multiple systems and organs. While hematological and biochemical profiles aren\'t definitive for diagnosis, recent studies have identified the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) as predictors of morbidity and mortality in critically ill human and dog patients. This study examined 100 dogs diagnosed with leishmaniasis, categorized by the International Renal Interest Society (IRIS) stages 1-4. Additionally, the dogs were divided based on whether they survived less or more than one year (L1Y and G1Y). Control group consisted of 43 dogs. The NLR increased as the disease progressed (IRIS 1-4), presenting statistically significant differences (P<0.05) when compared to the control group (2,37±2,08) IRIS 3 and 4 (4,59±13,39 and 6,99±12,86, respectively), and G1Y and L1Y (3,60±4,02 and 4,87±5,82, respectively). Significant changes in SII were only evident in short-term survivors (L1Y 951,93±1402) and advanced renal disease cases (IRIS 4 stage 1073,68±1901,09). Conversely, PLR remained largely unchanged. In conclusion, these results suggest that the neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) may serve as potential markers for assessing disease progression and prognosis in dogs diagnosed with leishmaniasis.