背景:身高与癌症风险增加有关,但大多数研究集中在西方人群。我们旨在评估东亚人的这种关系。
方法:利用来自中国嘉道理生物库(CKB)前瞻性队列的数据进行观察性分析。使用Cox比例风险模型估计调整后的风险比(HR)和相应的95%置信区间(CI)。两个样本孟德尔随机化(MR)分析使用韩国基因组和流行病学研究(KoGES)的数据探讨了身高和癌症之间的因果关系。日本生物银行(BBJ),还有CKB.
结果:在中位10.1年的随访中,发生了22,731例癌症。在观察性分析中,Bonferroni校正后,身高每增加10厘米与总体癌症风险显着相关(HR1.16,95%CI1.14-1.19,P<0.001),肺癌(1.18,95%CI1.12-1.24,P<0.001),食管癌(1.21,95%CI1.12-1.30,P<0.001),乳腺癌(1.41,95%CI1.31-1.53,P<0.001),宫颈癌(1.29,95%CI1.15-1.45,P<0.001)。身高每增加10cm提示淋巴瘤风险增加(1.18,95%CI1.04-1.34,P=0.010),结直肠癌(1.09,95%CI1.02-1.16,P=0.010),和胃癌(1.07,95%CI1.00-1.14,P=0.044)。在MR分析中,遗传预测的身高(每增加1个标准差,8.07cm)与肺癌(比值比[OR]1.17,95%置信区间[CI]1.02-1.35,P=0.0244)和胃癌(OR1.14,95%CI1.02-1.29,P=0.0233)的高风险相关。
结论:身高越高,患癌症的风险越高,肺癌,食道癌,乳腺癌,和子宫颈癌.我们的发现表明,身高可能是东亚人肺癌和胃癌的潜在危险因素。
BACKGROUND: Height is associated with increased cancer risk, but most studies focus on Western populations. We aimed to evaluate this relationship in East Asians.
METHODS: Observational analyses were performed utilizing data from China Kadoorie Biobank (CKB) prospective cohort. Adjusted hazard ratios (HRs) and corresponding 95 % confidence intervals (CIs) were estimated using Cox proportional hazards models. Two-sample Mendelian randomization (MR) analyses explored causal effects between height and cancer using data from Korean Genome and Epidemiology Study (KoGES), Biobank Japan (BBJ), and CKB.
RESULTS: Over a median 10.1-years follow-up, 22,731 incident cancers occurred. In observational analyses, after Bonferroni correction, each 10 cm increase in height was significantly associated with higher risk of overall cancer (HR 1.16, 95 % CI 1.14-1.19, P < 0.001), lung cancer (1.18, 95 % CI 1.12-1.24, P < 0.001), esophageal cancer (1.21, 95 % CI 1.12-1.30, P < 0.001), breast cancer (1.41, 95 % CI 1.31-1.53, P < 0.001), and cervix uteri cancer (1.29, 95 % CI 1.15-1.45, P < 0.001). Each 10 cm increase in height was suggestively associated with increased risk for lymphoma (1.18, 95 % CI 1.04-1.34, P = 0.010), colorectal cancer (1.09, 95 % CI 1.02-1.16, P = 0.010), and stomach cancer (1.07, 95 % CI 1.00-1.14, P = 0.044). In MR analyses, genetically predicted height (per 1 standard deviation increase, 8.07 cm) was suggestively associated with higher risk of lung cancer (odds ratio [OR] 1.17, 95 % confidence interval [CI] 1.02-1.35, P = 0.0244) and gastric cancer (OR 1.14, 95 % CI 1.02-1.29, P = 0.0233).
CONCLUSIONS: Taller height was significantly related to a higher risk for overall cancer, lung cancer, esophageal cancer, breast cancer, and cervix uteri cancer. Our findings suggest that height may be a potential causal risk factor for lung and gastric cancers among East Asians.