■在美国的美洲印第安人和阿拉斯加原住民患胃癌的几率很高。幽门螺杆菌感染是胃癌的重要危险因素,携带cagA基因的幽门螺杆菌菌株与更严重的胃肠道疾病有关。然而,对美洲印第安人和阿拉斯加原住民的幽门螺杆菌和cagA感染知之甚少,特别是在部落层面。我们评估了纳瓦霍族部落成员中幽门螺杆菌感染和cagA基因携带的患病率和危险因素。
■我们对来自纳瓦霍族的成年人进行了一项横断面研究。从参与者收集的粪便样品用液滴数字PCR分析幽门螺杆菌16S核糖体和cagA毒力基因。自我管理的健康和食物问卷被邮寄给参与者,以收集社会人口统计学信息,健康,生活方式,幽门螺杆菌感染的环境危险因素。Logistic回归分析了危险因素与幽门螺杆菌感染和cagA基因携带的相关性。
■在99名成年人中,中位年龄为45岁(年龄范围:18至79岁),73.7%为女性。约56.6%(95%CI:46.2-66.5)的参与者感染幽门螺杆菌。在幽门螺杆菌感染的参与者中,78.6%(95%CI:65.6-88.4)cagA基因阳性。没有发现相关危险因素与幽门螺杆菌和cagA基因阳性感染的显著关联。
■在基于社区的研究人群中,相当比例的成年部落成员患有幽门螺杆菌和cagA基因阳性感染.鉴于这些高比例,针对幽门螺杆菌感染的文化上适当的预防策略和干预措施为纳瓦霍国家的其他研究和胃癌预防提供了途径。
UNASSIGNED: American Indian and Alaska Native people in the United States experience high rates of stomach cancer. Helicobacter pylori infection is a significant risk factor for stomach cancer, and H. pylori strains that carry the
cagA gene are linked to greater gastrointestinal disease severity. Yet, little is known about H. pylori and
cagA infections in American Indian and Alaska Native people, particularly at the tribal level. We assessed the prevalence and risk factors of H. pylori infection and cagA gene carriage in tribal members from the Navajo Nation.
UNASSIGNED: We conducted a cross-sectional study with adults from the Navajo Nation. Stool samples collected from participants were analyzed with droplet digital PCR for H. pylori 16S ribosomal and
cagA virulence genes. Self-administered health and food questionnaires were mailed to participants to collect information on sociodemographic, health, lifestyle, and environmental risk factors for H. pylori infection. Logistic regression assessed the association between risk factors and H. pylori infection and cagA gene carriage.
UNASSIGNED: Among 99 adults, the median age was 45 (age range: 18 to 79 years), and 73.7% were female. About 56.6% (95% CI: 46.2-66.5) of participants were infected with H. pylori. Of H. pylori-infected participants, 78.6% (95% CI: 65.6-88.4) were
cagA-gene positive. No significant associations of relevant risk factors with H. pylori and
cagA-gene positive infections were noted.
UNASSIGNED: In a community-based study population, a substantial proportion of adult tribal members had H. pylori and cagA-gene positive infections. Given these high proportions, culturally appropriate prevention strategies and interventions addressing H. pylori infections present an avenue for additional research and stomach cancer prevention in the Navajo Nation.