未经授权:全身性糖皮质激素是自身免疫性水疱性疾病的一线治疗选择;然而,它们的长期使用与显著的毒性有关。
UNASSIGNED:评估类固醇保护剂的副作用,并将其与类固醇的副作用进行比较。
UNASSIGNED:我们搜索了Cochrane评论,Embase,MEDLINE,和Scopus在1978年10月至2020年5月之间使用关键字“大疱性类天疱疮,\"\"天疱疮,“\”自身免疫性水疱疾病,“和”副作用。“总共对31项随机对照试验和回顾性病例系列进行了严格评估。
UNASSIGNED:本综述共包括1685例自身免疫性水疱疾病患者,其中781人患有大疱性类天疱疮,904人患有寻常性天疱疮或叶性天疱疮。
UNASSIGNED:一个主要的限制是,由于佐剂通常与类固醇结合使用,在所审查的研究中,只有12项纳入了"仅使用类固醇"的研究,以便对副作用进行直接比较.此外,对于每种类固醇保护剂的具体副作用,文献不足且缺乏标准化等级报告.
未经评估:在未来,研究人员应该考虑实施不良事件通用术语标准,5.0版,用于报告所有副作用,以实现一致性和标准化。具有类似于糖皮质激素毒性指数的指数以量化这些副作用将是有用的。
UNASSIGNED: Systemic glucocorticoids are first-line treatment options for autoimmune blistering diseases; however, their long-term use is associated with significant toxicities.
UNASSIGNED: To evaluate the side effects of steroid-sparing agents and compare them with those of steroids.
UNASSIGNED: We searched Cochrane Reviews, Embase, MEDLINE, and Scopus between October 1978 and May 2020 using the keywords \"bullous pemphigoid,\" \"pemphigus,\" \"autoimmune blistering diseases,\" and \"side effects.\" A total of 31 randomized controlled trials and retrospective case series were critically appraised.
UNASSIGNED: This review includes a total of 1685 patients with autoimmune blistering diseases, of whom 781 had bullous pemphigoid and 904 had either pemphigus vulgaris or pemphigus foliaceous.
UNASSIGNED: A major limitation is that because adjuvants are generally used in combination with steroids, only 12 of the studies reviewed included a \"steroid-only\" arm to allow for a direct comparison of side effects. Additionally, there is inadequate literature and lack of standardized grade reporting of specific side effects of each steroid-sparing agent.
UNASSIGNED: In the future, researchers should consider implementing the Common Terminology Criteria for Adverse Events, version 5.0, for reporting of all side effects to allow for consistency and standardization. It would be useful to have an index similar to the Glucocorticoid Toxicity Index to quantify these side effects.