测试了在6和7位取代的6个2,4-二氨基蝶啶作为磺胺嘧啶对柔嫩艾美球虫的增效剂。2,4-二氨基-6,7-二异丙基蝶啶和2,4-二氨基-1\'-丙基吲哚（2\'，选择3':6,7)蝶啶用于进一步研究。对E.tenella增强的磺胺嘧啶和二异丙基蝶啶都增强了对E.necatrix的增强。10%的二异丙基蝶啶与磺胺嘧啶(或其他磺酰胺)的混合物似乎在治疗E.tenella和更多的E.necatrix方面提供了优势。
Six 2,4-diaminopteridines substituted in the 6 and 7 positions were tested as potentiators of sulphadimidine against Eimeria tenella. 2,4-Diamino-6,7-di-isopropylpteridine and 2,4-diamino-1\'-propylindolo(2\',3\':6,7)pteridine were selected for further study. Both potentiated sulphadimidine against E. tenella and the di-isopropylpteridine potentiated it against E. necatrix. A 10% mixture of the di-isopropylpteridine with sulphadimidine (or other sulphonamides) appears to offer advantages in the treatment of E. tenella and still more of E. necatrix.
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