目的:系统回顾和荟萃分析抗阻训练对生活质量的影响。疲劳,物理功能,以及被诊断患有癌症接受化疗的人的肌肉力量。
方法:电子数据库PubMed,CochraneCentral,CINAHL,SCOPUS和WebofScience进行了系统搜索,以比较抗阻训练对生活质量的影响的随机对照试验(RCT)。疲劳,物理功能,接受化疗的成年人的下半身和上半身肌肉力量。使用随机效应模型汇集标准化平均差(SMD)。使用随机试验的偏倚风险工具(RoB2)评估偏倚风险。
结果:包括561名参与者的7个随机对照试验。7项随机对照试验的汇总结果显示化疗期间的抗阻训练显著提高了下半身力量(n=555,SMD0.33,95%CI0.12to0.53,中等质量证据,I2=23%)与对照相比。没有证据表明阻力训练对生活质量有影响(n=373,SMD0.13,95%CI-0.15至0.42,低质量证据,I2=0%),疲劳(n=373,SMD-0.08,95%CI-0.37至0.22,低质量证据,I2=20%),身体功能(n=198,SMD0.61,95%CI-0.73至1.95,极低质量证据,I2=83%),或上身强度(n=413,SMD0.37,95%CI-0.07至0.80,非常低质量的证据,I2=69%)。
结论:与对照组相比,抗阻训练可以改善化疗患者的下半身力量。
OBJECTIVE: To systematically review and meta-analyse the efficacy of resistance training on quality of life (QOL), fatigue, physical function, and muscular strength in people diagnosed with cancer undergoing
chemotherapy.
METHODS: Electronic databases PubMed, Cochrane Central, CINAHL, SCOPUS and Web of Science were systematically searched for randomised controlled trials (RCTs) that compared the effects of resistance training to control on QOL, fatigue, physical function, and lower-body and upper-body muscular strength in adults undergoing
chemotherapy. Standardised mean differences (SMDs) were pooled using a random effects model. Risk of bias was assess using the risk of bias tool for randomised trials (RoB 2).
RESULTS: Seven RCTs encompassing 561 participants were included. The pooled results of seven RCTs showed that resistance training during
chemotherapy significantly improved lower-body strength (n = 555, SMD 0.33, 95% CI 0.12 to 0.53, moderate-quality evidence, I2 = 23%) compared to control. There was no evidence for an effect of resistance training on QOL (n = 373, SMD 0.13, 95% CI -0.15 to 0.42, low-quality evidence, I2 = 0%), fatigue (n = 373, SMD -0.08, 95% CI -0.37 to 0.22, low-quality evidence, I2 = 20%), physical function (n = 198, SMD 0.61, 95% CI -0.73 to 1.95, very low-quality evidence, I2 = 83%), or upper-body strength (n = 413, SMD 0.37, 95% CI -0.07 to 0.80, very low-quality evidence, I2 = 69%).
CONCLUSIONS: Resistance training may improve lower-body strength in patients undergoing
chemotherapy treatment compared to control.