■克里米亚-刚果出血热(CCHF)是一种严重且可能致命的疾病。Hyalomma属的滴答叮咬是CCHF传播给人类的主要来源。负责CCHF的病毒是CCHF病毒(CCHFV)。它是一种单链负感RNA病毒。该病毒属于Nairoviridae家族中的Orthonairovibrae属。它发生在横跨中东的广阔地理区域,中国西部,南亚,东南欧,和大部分非洲。本研究旨在评估CCHFV引起国际关注的突发公共卫生事件的致病性和潜在风险。
■我们从PubMed搜索了最新的相关信息,谷歌学者,和使用克里米亚-刚果出血热的Scopus数据库,蜱传病毒,和奈罗病毒作为关键字。
■病死率(CFR)因地区而异。在某些情况下,它可以超过30%。CCHFV基因组中的三个片段(L,M,和S)在大小和功能上不同。尚不清楚CCHFV的致病性是否基于基因组多样性而变化。CCHFV可以通过蜱叮咬传播,处理受感染的蜱,接触受感染的人,受污染的体液,等等。广泛的严重程度与CCHF相关,从没有明显原因的中度发烧到血管通透性增加,几个器官衰竭,出血,和震惊。具有高级隔离单位的医院应该是治疗CCHF患者的首选。个人安全设备在医疗保健中至关重要,以防止病毒传播。在农场环境中,使用综合虫害管理技术,尽量减少蜱出没地区的活动,在长袖和裤子中适当穿衣将有助于降低通过蜱叮咬感染CCHFV的风险。
■除了支持性治疗方法外,没有批准的疫苗接种或治疗方法。因此,科学家建议对高风险暴露病例进行早期利巴韦林治疗。
UNASSIGNED: Crimean-Congo hemorrhagic fever (CCHF) is a severe and potentially lethal illness. Tick bites of the Hyalomma genus are the primary source of transmission of CCHF to humans. The virus responsible for CCHF is the CCHF virus (CCHFV). It is a single-stranded negative sensed RNA virus. The virus belongs to the Orthonairoviridae genus within the Nairoviridae family. It occurs in an extensive geographical area spanning the Middle East, western China, southern Asia, southeastern Europe, and much of Africa. The current study aimed to evaluate the pathogenicity and potential risk of CCHFV to cause a public health emergency of international concern.
UNASSIGNED: We searched updated relevant information from PubMed, Google Scholar, and Scopus databases using Crimean-Congo hemorrhagic fever, tick-borne virus, and Nairovirus as keywords.
UNASSIGNED: The case fatality rate (CFR) varies by region. It can be more than 30% in some cases. Three segments in the genome of CCHFV (L, M, and S) are different in size and function. It is unknown whether the pathogenicity of CCHFV varied based on the genomic diversity. CCHFV can be transmitted through tick bites, handling of infected ticks, contact with infected humans, contaminated body fluids, and so on. A wide range of severity is associated with CCHF, ranging from a moderate fever with no apparent cause to increased vascular permeability, failure of several organs, bleeding, and shock. Hospitals with high-level isolation units should be the first choice for treating CCHF patients. Individual safety equipment is crucial in healthcare to prevent the spread of the virus. In the farm environment, using integrated pest management techniques, minimizing activity in tick-infested regions, and dressing appropriately in long sleeves and pants will help to reduce the risk of CCHFV infection via tick bites.
UNASSIGNED: There are no approved vaccinations or therapeutics for CCHF except supportive therapeutic approaches. Therefore, scientists recommend early ribavirin therapy for cases of high-risk exposures.