■这项研究的目的是检查高度近视(HM)眼的网眼(LC)构型特征。
■2011年北京眼科研究的参与者,没有视神经或视网膜疾病,随机选择使用视神经乳头(ONH)的三维光学相干断层扫描图像检查LC深度(LCD)和LC倾斜(LCT)。LCD和LCT被测量为LC平面与两个参考平面之间的距离和角度。包括布鲁赫膜开口(BMO)平面和巩膜周围(PPS)平面,分别。在水平和垂直B扫描中测量每个参数。
■该研究包括685名59.6±7.7岁的个体(685只眼),包括72只HM眼睛和613只非HM眼睛。LCD测量显示,在两个水平方向上,HM眼睛和非HM眼睛之间没有显着差异(HM眼睛的LCD-BMO=421.83±107.86µm与447.24±104.94µm,适用于非HM眼睛,P=0.18;LCD-PPS=406.39±127.69µmvs.394.00±101.64µm,P=1.00)和垂直方向(LCD-BMO=435.78±101.29µmvs.450.97±106.54µm,P=0.70;LCD-PPS=401.62±109.9µmvs.379.85±110.35µm,P=0.35)。然而,HM眼的LCT水平明显比非HM眼的阴性(倾斜)(LCT-BMO=-4.38±5.94度与-0.04±5.86度,P<0.001;LCT-PPS=-3.16±5.23度vs.-0.94±4.71度,P=0.003),但不垂直(P=1.00)。
■尽管HM和非HM眼睛之间的LCD没有显着差异,HM眼LCT阴性,提示LC的颞侧或下侧更靠近参考平面。这些发现提供了对HM和非HM眼之间LC和ONH的形态和结构变化的见解。
UNASSIGNED: The purpose of this study was to examine characteristics of lamina cribrosa (LC) configuration in highly myopic (HM) eyes.
UNASSIGNED: Participants from the Beijing Eye Study 2011, free of optic nerve or retinal diseases, were randomly selected to examine LC depth (LCD) and LC tilt (LCT) using three-dimensional optical coherent tomography images of the optic nerve head (ONH). LCD and LCT were measured as the distance and angle between the LC plane with two reference planes, including the Bruch\'s membrane opening (BMO) plane and the peripapillary sclera (PPS) plane, respectively. Each parameter was measured in both horizontal and vertical B-scans.
UNASSIGNED: The study included 685 individuals (685 eyes) aged 59.6 ± 7.7 years, including 72 HM eyes and 613 non-HM eyes. LCD measurements showed no significant differences between HM eyes and non-HM eyes in both horizontal (LCD-BMO = 421.83 ± 107.86 µm for HM eyes vs. 447.24 ± 104.94 µm for non-HM eyes, P = 0.18; and LCD-PPS = 406.39 ± 127.69 µm vs. 394.00 ± 101.64 µm, P = 1.00) and vertical directions (LCD-BMO = 435.78 ± 101.29 µm vs. 450.97 ± 106.54 µm, P = 0.70; and LCD-PPS = 401.62 ± 109.9 µm vs. 379.85 ± 110.35 µm, P = 0.35). However, the LCT was significantly more negative (tilted) in HM eyes than in non-HM eyes horizontally (LCT-BMO = -4.38 ± 5.94 degrees vs. -0.04 ± 5.86 degrees, P < 0.001; and LCT-PPS = -3.16 ± 5.23 degrees vs. -0.94 ± 4.71 degrees, P = 0.003), but not vertically (P = 1.00).
UNASSIGNED: Although LCD did not differ significantly between HM and non-HM eyes, LCT was more negative in HM eyes, suggesting that the temporal or inferior side of the LC was closer to the reference plane. These findings provide insights into morphological and structural changes in the LC and ONH between HM and non-HM eyes.