一个两岁的孩子,Spyed女性,BichonFrise狗不愿运动,背痛,经常坐下来。多发性骨质溶解,骨膜增生,在X线摄影中观察到T11-13椎体终板硬化,计算机断层扫描,和磁共振成像。尿液样本的细菌培养,血液的聚合酶链反应(PCR),犬布鲁氏菌抗体检测呈阳性.因此,由B引起的椎间盘炎诊断为犬并给予多西环素。临床症状消退,随后培养和PCR结果为阴性。6个月后停用强力霉素。2周后临床症状复发,并开始多西环素和恩诺沙星的联合治疗。尽管9个月后没有观察到临床症状,细菌培养和PCR均为阴性,抗体滴度保持在1:200或更高。狗将继续服用抗生素,直到抗体滴度下降。据我们所知,这是首例B.临床感染病例报告在大韩民国,犬与犬椎间盘炎有关。尽管抗生素治疗可能会改善布鲁氏菌病的临床症状,由于布鲁氏菌逃避宿主免疫系统的各种策略,这种疾病无法治愈。具体来说,它可以在宿主细胞内增殖和复制,导致治疗效果较差的环境。此外,由于其人畜共患的潜力,业主和兽医应考虑终身管理或安乐死。
A 2-year-old, spayed female, Bichon Frise dog was presented with reluctance to exercise, back pain, and frequent sitting down. Multiple osteolysis, periosteal proliferation, and sclerosis of the vertebral endplates of T11-13 were observed in the radiography, computed tomography, and magnetic resonance imaging. The bacterial culture of the urine specimen, the polymerase chain reaction (PCR) of the blood, and the antibody tests were positive for Brucella canis. Accordingly, discospondylitis caused by B. canis was diagnosed and doxycycline was administered. The clinical signs resolved and the culture and PCR results were negative afterwards. Doxycycline was discontinued after 6 months. The clinical signs recurred 2 weeks later, and the combination treatment of doxycycline and enrofloxacin was initiated. Though no clinical signs were observed after 9 months and the bacterial cultures and PCR were negative, the antibody titre remained at 1 : 200 or more. The dog will continue taking antibiotics until the antibody titre drops. To the best of our knowledge, this is the first case report of a clinical infection of B. canis associated with canine discospondylitis in the Republic of Korea. Although the clinical signs of brucellosis might improve with antibiotic treatment, the disease cannot be cured due to Brucella\'s various strategies to evade host immune systems. Specifically, it can proliferate and replicate within the host cells, resulting in an environment that makes treatment less effective. Furthermore, owing to its zoonotic potential, owners and veterinarians should consider lifelong management or euthanasia.