■神经调节素4(Nrg4)是一种棕色脂肪组织来源的脂肪因子,极大地影响全身代谢并改善代谢紊乱。尽管Nrg4的异常循环水平在肥胖中很常见,这种巴托克的低水平或高水平是否与代谢性疾病的发作有关,仍然难以捉摸。
■为了评估Nrg4水平及其作为预测肥胖严重程度的可行生物标志物的作用,妊娠期糖尿病(GDM),2型糖尿病(T2DM),非酒精性脂肪性肝病(NAFLD),和心血管疾病(CVD)。
■使用著名的搜索引擎系统地进行了相关研究的搜索,包括PubMed,谷歌学者,和Embase,遵循PRISMA准则。
■大量临床证据报道肥胖患者血清/血浆Nrg4水平较低,这些水平与代谢综合征的指标成反比,包括体重指数,腰围,甘油三酯,空腹血糖,胰岛素抵抗和高敏C反应蛋白的稳态模型评估。低循环Nrg4水平可能有助于预测病态肥胖,以及随后的GDM,T2DM,NAFLD,和CVD。
■目前的临床证据强调,Nrg4的循环水平在病态肥胖中降低,它还强调了Nrg4可能作为肥胖相关代谢性疾病的潜在预后生物标志物。
UNASSIGNED: Neuregulin 4 (Nrg4) is a brown adipose tissue-derived adipokine that greatly affects systemic metabolism and improves metabolic derangements. Although abnormal circulating levels of Nrg4 are common in obesity, it remains elusive whether low or elevated levels of this batokine are associated with the onset of metabolic diseases.
UNASSIGNED: To assess Nrg4 levels and its role as a feasible biomarker to predict the severity of obesity, gestational diabetes mellitus (GDM), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and cardiovascular diseases (CVD).
UNASSIGNED: A search for relevant studies was performed systematically using prominent search engines, including PubMed, Google Scholar, and Embase, by following PRISMA guidelines.
UNASSIGNED: Ample clinical evidence reported low serum/plasma levels of Nrg4 in obesity and these were inversely proportional to the indices of metabolic syndrome, including body mass index, waist circumference, triglycerides, fasting plasma glucose, and homoeostatic model assessment for insulin resistance as well as high-sensitivity C-reactive protein. Low circulating Nrg4 levels may aid in the prediction of morbid obesity, and subsequent GDM, T2DM, NAFLD, and CVD.
UNASSIGNED: Current clinical evidence emphasizes that the circulating levels of Nrg4 are decreased in morbid obesity, and it also highlights that Nrg4 May serve as a potential prognostic biomarker for obesity-related metabolic diseases.