背景:气管,支气管,近几十年来,肺癌(TBL)已显示出明显的女性化和年轻发病趋势。因此,我们的目标是研究全球育龄妇女中TBL患病率的最新模式,区域,和国家规模。
方法:为了评估TBL在育龄妇女中的流行趋势,我们计算了估计的年度百分比变化(EAPC),年龄标准化发病率(ASIR),年龄标准化死亡率(ASDR),1990年至2019年,204个国家和地区的残疾调整生命年(DALYs)。这些计算基于2019年全球疾病负担(GBD)数据库。
结果:从1990年到2019年,全球发病率的绝对数量有所增加,死亡,育龄妇女的TBL和DALYs。然而,ASIR,ASDR,年龄标准化的DALY率在此期间下降,EAPC为-0.77(95%置信区间[CI]:-1.03至-0.51),-1.08(95%CI:-1.34至-0.82),和-1.10(95%CI:-1.36至-0.84),分别。即使在社会人口指数(SDI)较高的地区也观察到了这种趋势。东亚一直拥有最高的ASIR,ASDR,和年龄标准化的DALY率,但是有下降的趋势。相反,撒哈拉以南非洲东部显示出日益增加的负担模式。在单独研究国家时,摩纳哥,格陵兰,帕劳的ASIR最高。此外,在大多数国家,TBL的ASIR随年龄增长而增加,尤其是35-49岁的女性。
结论:尽管ASIR在全球范围内有所下降,ASDR,在过去的三十年中,育龄妇女的TBL的年龄标准化DALY率,在中低SDI地区仍有令人不安的增长。至关重要的是,在这些地区实施有效的预防和治疗措施,以应对这一趋势。
BACKGROUND: Trachea,
bronchus, and lung (TBL) cancer has demonstrated a discernible feminization and a tendency towards younger onset in recent decades. Therefore, our objective is to examine the most recent patterns in the worldwide prevalence of TBL among women of reproductive age on a global, regional, and national scale.
METHODS: To assess the prevalence trends of TBL in women of reproductive age, we calculated the estimated annual percentage change (EAPC), age-standardized incidence rate (ASIR), age-standardized death rate (ASDR), and disability-adjusted life years (DALYs) for 204 countries and territories from 1990 to 2019. These calculations were based on the Global Burden of Disease (GBD) 2019 database.
RESULTS: From 1990 to 2019, there was a global increase in the absolute number of incidence cases, deaths, and DALYs of TBL in women of reproductive age. However, the ASIR, ASDR, and age-standardized DALY rates were decreasing over this period, with EAPC of -0.77 (95 % confidence interval [CI]: -1.03 to -0.51), -1.08 (95 % CI: -1.34 to -0.82), and -1.10 (95 % CI: -1.36 to -0.84), respectively. This trend was observed even in regions with higher Socio-Demographic Index (SDI). East Asia consistently had the highest ASIR, ASDR, and age-standardized DALY rate, but there was a decreasing trend. Conversely, Eastern Sub-Saharan Africa displayed an increasing burden pattern. When examining countries individually, Monaco, Greenland, and Palau had the highest ASIR. Moreover, in most countries, the ASIR for TBL increased with age, particularly among women aged 35-49 years.
CONCLUSIONS: Despite a global decline in ASIR, ASDR, and age-standardized DALY rates for TBL in women of reproductive age over the past three decades, there is still a troubling increase observed in low- and low-middle SDI regions. It is crucial to implement effective preventive and curative measures in these regions in order to address this concerning trend.