全球出生率最近呈现下降趋势,暴露于环境污染物已被确定为影响女性生殖健康的潜在因素。邻苯二甲酸酯已广泛用作塑料容器中的增塑剂,儿童玩具,和医疗设备,它们无处不在的存在和内分泌干扰的潜力已经引起了特别的关注。邻苯二甲酸盐暴露与各种不良健康结果有关,包括生殖疾病。鉴于许多邻苯二甲酸酯逐渐被禁止,越来越多的邻苯二甲酸酯替代品变得流行,例如二(异壬基)环己烷-1,2-二羧酸酯(DINCH),己二酸二(2-乙基己基)酯(DEHA),和对苯二甲酸二(2-乙基己基)酯(DEHTP),它们开始产生广泛的环境影响。研究表明,许多邻苯二甲酸酯替代品可能会通过改变发情周期来破坏女性的生殖功能,导致卵巢卵泡闭锁,延长妊娠周期,这引起了人们对其潜在健康风险的日益担忧。在这里,我们总结了邻苯二甲酸酯及其常见替代品在不同女性模型中的作用,影响生殖系统的暴露水平,以及对女性生殖障碍的影响,不良妊娠结局,和后代发育。此外,我们仔细研究邻苯二甲酸盐及其替代品对激素信号的影响,氧化应激,和细胞内信号,以探索对女性生殖健康的作用机制,因为这些化学物质可能通过内分泌干扰直接或间接影响生殖组织。鉴于女性生殖能力下降的全球趋势以及邻苯二甲酸酯及其替代品对女性生殖健康产生负面影响的潜在能力,需要进行更全面的研究,以了解它们对人体的影响及其潜在机制。这些发现可能对改善女性生殖健康,进而减少怀孕期间并发症的数量具有重要作用。
The global birth rate has recently shown a decreasing trend, and exposure to environmental pollutants has been identified as a potential factor affecting female reproductive health. Phthalates have been widely used as plasticizers in plastic containers, children\'s toys, and medical devices, and their ubiquitous presence and endocrine-disrupting potential have already raised particular concerns. Phthalate exposure has been linked to various adverse health outcomes, including reproductive diseases. Given that many phthalates are gradually being banned, a growing number of phthalate alternatives are becoming popular, such as di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH), di(2-ethylhexyl) adipate (DEHA), and di(2-ethylhexyl) terephthalate (DEHTP), and they are beginning to have a wide range of environmental effects. Studies have shown that many phthalate alternatives may disrupt female reproductive function by altering the estrous cycle, causing ovarian follicular atresia, and prolonging the gestational cycle, which raises growing concerns about their potential health risks. Herein, we summarize the effects of phthalates and their common alternatives in different female models, the exposure levels that influence the reproductive system, and the effects on female reproductive impairment, adverse pregnancy outcomes, and offspring development. Additionally, we scrutinize the effects of phthalates and their alternatives on hormone signaling, oxidative stress, and intracellular signaling to explore the underlying mechanisms of action on female reproductive health, because these chemicals may affect reproductive tissues directly or indirectly through endocrine disruption. Given the declining global trends of female reproductive capacity and the potential ability of phthalates and their alternatives to negatively impact female reproductive health, a more comprehensive study is needed to understand their effects on the human body and their underlying mechanisms. These findings may have an important role in improving female reproductive health and in turn decreasing the number of complications during pregnancy.