■优势动脉供血是肝细胞癌(HCC)的特征。然而,目前尚不清楚血液供应是否可以预测肝癌患者肝切除术后的预后。这项回顾性研究调查了在三相肝CT上估计的门静脉和动脉血供的预后价值(作为门静脉系数,PVC,和肝动脉系数,HAC,分别)在肝切除术后的HCC患者中。
■在第二附属医院进行肝切除术前2周进行了三相肝CT检查并接受了R0肝切除术的HCC患者,昆明医科大学2016年1月1日至2020年12月31日进行回顾性筛查。他们的PVC和HAC,使用最小绝对收缩率和选择算子和Cox比例风险回归模型,分析了其他变量对总生存期(OS)和无复发生存期(RFS)的预测.
■对四百十九名患者(53.2±10.6岁,370名男性)进行了评估。较短的OS与较高的血白蛋白和总胆红素等级独立相关[风险比(HR)2.020,95%置信区间(CI)1.534-2.660],巴塞罗那临床肝癌(BCLC)分期较高(HR1.514,95%CI1.290-1.777),PVC≤0.386(HR1.628,95%CI1.149-2.305),和HAC>0.029(HR1.969,95%CI1.380-2.809)。较短的RFS与男性独立相关(HR1.652,95%CI1.005-2.716),较高的血清甲胎蛋白≥400ng/mL(HR1.672,95%CI1.236-2.263),较高的BCLC分期(HR1.516,95%CI1.300-1.768),肿瘤PVC≤0.386(HR1.641,95%CI1.198-2.249),肿瘤HAC>0.029(HR1.455,95%CI1.060-1.997)。
■肝切除术前的肿瘤PVC或HAC对于独立预测HCC患者的术后生存率是有价值的。
UNASSIGNED: The dominant artery blood supply is a characteristic of hepatocellular carcinoma (HCC). However, it is not known whether the blood supply can predict the post-hepatectomy prognosis of patients with HCC. This retrospective study investigated the prognostic value of the portal venous and arterial blood supply estimated on triphasic liver CT (as a portal venous coefficient, PVC, and hepatic arterial coefficient, HAC, respectively) in patients with HCC following hepatectomy.
UNASSIGNED: HCC patients who were tested by triphasic liver CT 2 weeks before hepatectomy and received R0 hepatectomy at the Second Affiliated Hospital, Kunming Medical University between January 1, 2016 and December 31, 2020, were retrospectively screened. Their PVC and HAC, and other variables were analyzed for the prediction of overall survival (OS) and recurrence-free survival (RFS) using the least absolute shrinkage and selection operator and Cox proportional hazard regression models.
UNASSIGNED: Four hundred and nineteen patients (53.2 ± 10.6 years of age and 370 men) were evaluated. A shorter OS was independently associated with higher blood albumin and total bilirubin grade [hazard ratio (HR) 2.020, 95% confidence interval (CI) 1.534-2.660], higher Barcelona Clinic Liver Cancer (BCLC) stage (HR 1.514, 95% CI 1.290-1.777), PVC ≤ 0.386 (HR 1.628, 95% CI 1.149-2.305), and HAC > 0.029 (HR 1.969, 95% CI 1.380-2.809). A shorter RFS was independently associated with male (HR 1.652, 95% CI 1.005-2.716), higher serum α-fetoprotein ≥ 400 ng/mL (HR 1.672, 95% CI 1.236-2.263), higher BCLC stage (HR 1.516, 95% CI 1.300-1.768), tumor PVC ≤ 0.386 (HR 1.641, 95% CI 1.198-2.249), and tumor HAC > 0.029 (HR 1.455, 95% CI 1.060-1.997).
UNASSIGNED: Tumor PVC or HAC before hepatectomy is valuable for independently predicting postoperative survival of HCC patients.